Emphysema and Mechanical Stress-Induced Lung Remodeling
Department of Biomedical Engineering, Boston University, Boston, Massachusetts.Physiology (Impact Factor: 4.86). 11/2013; 28(6):404-13. DOI: 10.1152/physiol.00041.2013
Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. We present possible new directions and an integrated multiscale view that may prove useful in finding solutions for this disease.
- Physiology 11/2013; 28(6):368-9. DOI:10.1152/physiol.00052.2013 · 4.86 Impact Factor
- Physiology 11/2013; 28(6):366-7. DOI:10.1152/physiol.00054.2013 · 4.86 Impact Factor
- Physiology 11/2013; 28(6):363-5. DOI:10.1152/physiol.00051.2013 · 4.86 Impact Factor
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