Article

Prevalence, clearance, and incidence of human papillomavirus type-specific infection at the anal and penile site of HIV-infected men.

†Department of Sanitat i Anatomia Animal, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Sexually transmitted diseases (Impact Factor: 2.75). 08/2013; 40(8):611-8.. DOI: 10.1097/01.OLQ.0000430798.61475.08.

ABSTRACT BACKGROUND: We studied the type-specific infection of human papillomavirus (HPV)
at the anal canal and penile site in a cohort of HIV-infected men.
METHODS: Prevalence, clearance, and incidence of specific HPV types in the anal
canal and penis were determined in 733 HIV-infected men from the Spanish CAn Ruti
HIV+ Men ([CARH•MEN]) cohort (538 men who have sex with men [MSM] and 195
heterosexual men).
RESULTS: In both groups, the most prevalent high-risk type was HPV-16 (anal canal
[31.6% MSM; 6.8% heterosexual] and penis [4.8% MSM; 6.8% heterosexual]). The most
prevalent low-risk type was HPV-6 (anal canal [23.2% MSM; 12.8% heterosexual],
penis [8.1% MSM; 8.9% heterosexual]). Anal prevalence was significantly higher in
MSM, as was incidence, except for HPV-16, which was similar between male groups
(5.9 new cases per 1000 person-months [95% confidence interval, 4.3-7.9] in MSM;
4.4 [95% confidence interval, 2.5-7.2] in heterosexual men; P > 0.05). The anal
clearance rate of the different HPV types and retention time of infection were
similar in both groups, as well as the HPV infection of the penis.
CONCLUSIONS: HIV-infected MSM had a high prevalence of HPV infection at the anal
canal; however, heterosexual HIV-infected men were also at risk for acquiring and
sustaining persistent high-risk HPV types at the anal and penile site and are at
risk for developing dysplasia in the future. All HIV-infected men should be
recommended for routinely anal HPV screening.

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