Article

Deep brain stimulation (DBS) at the interface of neurology and psychiatry

The Journal of clinical investigation (Impact Factor: 13.77). 11/2013; 123(11):4546-56. DOI: 10.1172/JCI68341
Source: PubMed

ABSTRACT Deep brain stimulation (DBS) is an emerging interventional therapy for well-screened patients with specific treatment-resistant neuropsychiatric diseases. Some neuropsychiatric conditions, such as Parkinson disease, have available and reasonable guideline and efficacy data, while other conditions, such as major depressive disorder and Tourette syndrome, have more limited, but promising results. This review summarizes both the efficacy and the neuroanatomical targets for DBS in four common neuropsychiatric conditions: Parkinson disease, Tourette syndrome, major depressive disorder, and obsessive-compulsive disorder. Based on emerging new research, we summarize novel approaches to optimization of stimulation for each neuropsychiatric disease and we review the potential positive and negative effects that may be observed following DBS. Finally, we summarize the likely future innovations in the field of electrical neural-network modulation.

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    • "mechanosensation), which has already been demonstrated in macaques via microstimulation of somatosensory cortex (Berg et al., 2013; O'Doherty et al., 2011; Tabot et al., 2013). Beyond the experimental domain, electrical stimulation of the brain, spinal cord and peripheral nerves via implanted electrodes is in use clinically for the treatment of movement disorders (Williams and Okun, 2013), psychiatric disorders (Williams and Okun, 2013), chronic pain (Plow et al., 2012), epilepsy (Bergey, 2013), neurogenic bladder (Lay and Das, 2012) and for the restoration of lost sensory functions such as hearing (Carlson et al., 2012; Shepherd et al., 2013). Currently, the most commercially successful sensory prosthesis is the cochlear implant for treatment of neural deafness, of which the US National Institutes of Health reports there were 324,200 recipients worldwide in "
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    ABSTRACT: The field of neurobionics offers hope to patients with sensory and motor impairment. Blindness is a common cause of major sensory loss, with an estimated 39 million people worldwide suffering from total blindness in 2010. Potential treatment options include bionic devices employing electrical stimulation of the visual pathways. Retinal stimulation can restore limited visual perception to patients with retinitis pigmentosa, however loss of retinal ganglion cells precludes this approach. The optic nerve, lateral geniculate nucleus and visual cortex provide alternative stimulation targets, with several research groups actively pursuing a cortically-based device capable of driving several hundred stimulating electrodes. While great progress has been made since the earliest works of Brindley and Dobelle in the 1960s and 70s, significant clinical, surgical, psychophysical, neurophysiological, and engineering challenges remain to be overcome before a commercially-available cortical implant will be realized. Selection of candidate implant recipients will require assessment of their general, psychological and mental health, and likely responses to visual cortex stimulation. Implant functionality, longevity and safety may be enhanced by careful electrode insertion, optimization of electrical stimulation parameters and modification of immune responses to minimize or prevent the host response to the implanted electrodes. Psychophysical assessment will include mapping the positions of potentially several hundred phosphenes, which may require repetition if electrode performance deteriorates over time. Therefore, techniques for rapid psychophysical assessment are required, as are methods for objectively assessing the quality of life improvements obtained from the implant. These measures must take into account individual differences in image processing, phosphene distribution and rehabilitation programs that may be required to optimize implant functionality. In this review, we detail these and other challenges facing developers of cortical visual prostheses in addition to briefly outlining the epidemiology of blindness, and the history of cortical electrical stimulation in the context of visual prosthetics.
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    • "For these treatment - resistant patients , high - frequency electrical stimulation of sub - cortical brain structures , known as deep brain stimulation ( DBS ) , presents a highly successful therapeutic alternative ( Benabid et al . , 2005 ; Williams and Okun , 2013 ) . DBS is FDA - approved for the treatment of Parkinson ' s disease ( PD ) and essential tremor ( ET ) ( Benabid et al . "
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    • "In another study, direct electrical stimulation (DES) over part of the primary motor cortex that controls hand and wrist movements was used in a randomized clinical trial to facilitate rehabilitation for recovery of upper limb motor function in stroke patients (Harvey and Winstein, 2009). Nevertheless, perhaps the greatest therapeutic efficacy has been observed with deep brain stimulation of subcortical structures in patients with severe neurological disorders (e.g., the subthalamic nucleus in Parkinson's disease; Williams and Okun, 2013). This is puzzling, since the function of the neocortex is better understood than many subcortical structures (cortex is more accessible for neurophysiological and neuroimaging experiments). "
    The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 04/2014; 34(18):6125-6127. DOI:10.1523/JNEUROSCI.0590-14.2014 · 6.75 Impact Factor
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