Antiviral-Resistant Fulminant Herpes Hepatitis in Pregnancy

Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
AJP Reports 10/2013; 3(2):87-90. DOI: 10.1055/s-0033-1343791
Source: PubMed

ABSTRACT Fulminant herpes hepatitis with disseminated extrahepatic involvement in pregnancy is rare and carries a high mortality risk. Although acyclovir remains standard first-line therapy, effective management of acyclovir-resistant disseminated herpes simplex virus (HSV) in pregnancy remains elusive. We present a case of disseminated HSV resistant to both acyclovir and foscarnet, the first double-agent resistant case in pregnancy reported in the literature to date. In this case, therapeutic delivery was the ultimate treatment resulting in full recovery.

Download full-text


Available from: Nancy C Chescheir, Aug 20, 2014
23 Reads
  • Archives of Dermatology 11/1977; 113(10):145-9. DOI:10.1001/archderm.113.10.145 · 4.79 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A case is described of herpetic hepatitis in a pregnant woman with primary herpetic stomatitis. Intranuclear inclusion bodies and virus particles were found in hepatocytes, and herpes virus was isolated from a liver biopsy and from oral swabs but not from blood. From rising titres of neutralizing and complement-fixing antibody it is concluded that the oral infection was a primary one. Factors predisposing to the hepatitis are discussed.
    Journal of Clinical Pathology 02/1969; 22(1):60-6. DOI:10.1136/jcp.22.1.60 · 2.92 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine whether abnormalities in T-cell subsets might help to explain the immunodeficient state in pregnancy, we used monoclonal antibodies to enumerate the proportion and absolute number of subsets of T cells and other peripheral-blood mononuclear cells from normal pregnant women, post-partum women, and newborns. We found a significant decrease in relative and absolute numbers of helper T lymphocytes (T4+ cells) throughout pregnancy. Normalization of T4+ cells occurred during the third to fifth month post partum. Our findings support previous evidence of maternal immunodeficiency during pregnancy and indicate that it may occur because of a reduction in the population of helper T cells.
    New England Journal of Medicine 09/1982; 307(6):352-6. DOI:10.1056/NEJM198208053070606 · 55.87 Impact Factor
Show more