Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA (A.M.V.)Circulation (Impact Factor: 14.43). 10/2013; 128(17):e344-5. DOI: 10.1161/CIRCULATIONAHA.113.003858
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ABSTRACT: Introduction This study is to investigate the distribution of inhibitory and activating killer immunoglobulin like receptors (KIRs) and the combination of KIR/HLA-C in women with preeclampsia in the Chinese Han population compared with the control. Methods 271 patients with preeclampsia were enrolled in this study. The PCR sequence-specific primers (SSP) method was used to detect the inhibitory/activating KIRs and the HLA-C gene polymorphism. Results Our result showed that decreased numbers of individual activating KIR genes (2DS2, 2DS3, 2DS5) was observed in patients with preeclampsia and the gene frequency of total KIRs was also lower in patients compared to that of the control subjects (P =0.03). The frequency of KIR2DL1 gene was increased in the mother with preeclampsia when the fetus has a HLA-C2 alleles. Conclusion The results suggest that a genetic variation at the KIR locus might influence the susceptibility to preeclampsia in the Chinese Han population. Lacking of activating KIRs could potentially lower the uNK cell activation, thereby contributing to pathogenesis of preeclampsia. Moreover, the matching of the inhibitory or activating KIRs/HLA combination at the maternal-fetal interface seems to play a regulatory role in the occurrence of preeclampsia.Placenta 06/2014; 36(4). DOI:10.1016/j.placenta.2014.05.008 · 2.71 Impact Factor
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