A Study of the Short-Term Effect of Artificial Tears on Contrast Sensitivity in Patients With Sjogren's Syndrome

Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, 200031, China.
Investigative ophthalmology & visual science (Impact Factor: 3.66). 10/2013; 54(13). DOI: 10.1167/iovs.13-11798
Source: PubMed

ABSTRACT Purpose: This study was designed to measure the effect of different artificial tears on the contrast sensitivity of Sjgren's syndrome patients from 5 minutes to 4 hours after instillation. Methods: Ten normal subjects and ten subjects with ocular manifestations of Sjgren's syndrome were compared at baseline, including staining scores, a dry eye questionnaire and contrast sensitivity testing. Changes in contrast sensitivity in the Sjgren's syndrome group were measured over a four hour period after instillation of a variety of artificial tears. Results: Statistically significant differences in staining, subjective questionnaire scores and contrast sensitivity were measured between the normal and Sjgren's syndrome groups. Statistically significant changes in contrast sensitivity were measured over time after artificial tear instillation, with the greatest effect at 3-6 cycles per degree. The more muco-adhesive artificial tears demonstrated a significantly greater effect. Conclusions: The effects of artificial tears on measured contrast sensitivity in dry eye patients in the post-instillation period of 5 minutes to 4 hours appear limited, but an artificial tear with more muco-adhesive properties showed more benefit than those which do not. Modest effects on contrast sensitivity, primarily at medium spatial frequencies, were observed with the more muco-adhesive formulations.

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