Article

Les perturbateurs endocriniens quel risque pour la santé

Medecine Therapeutique Medecine de la Reproduction 10/2013; 13(2011):102-9. DOI: 10.1684/mte.2011.0352

ABSTRACT Au cours de ces 20 dernières années, l’exposition à des produits perturbateurs de la fonction endocrinienne s’est accrue, ce qui a augmenté les inquiétudes vis-à-vis des risques encourus pour la santé. Qu’ils soient apportés par l’alimentation ou via l’air, ces perturbateurs entraînent des effets néfastes sur la santé de la population. Le mécanisme de toxicité est lié essentiellement à l’action sur les hormones endogènes en interférant avec leur synthèse, leur transport, leur liaison, leur action ou leur élimination. Les effets de perturbateurs endocriniens s’observent principalement sur l’axe hypothalamus-hypophyse-gonade et l’axe hypothalamushypophyse-thyroïde. Plusieurs substances sont classées comme perturbateurs endocriniens, les plus étudiées sont les pesticides organochlorés, les dioxines, les phtalates et le bisphénol A et la liste n’est pas exhaustive. L’objectif de ce travail est de passer en revue les connaissances acquises dans le domaine de perturbation endocrinienne, les substances impliquées, leurs mécanismes et les effets sur la santé.

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May 20, 2014