Norovirus infection in immunocompromised children and children with hospital-acquired acute gastroenteritis.
ABSTRACT Norovirus (NoV) is a leading cause of acute viral gastroenteritis among children, yet its burden of disease among immunocompromised hosts and its role in hospital acquired infections (HAI) is not well characterized. To determine the prevalence, genotypes, and NoV loads among immunocompromised children and children with HAI, residual stool samples, and clinical data were collected at two major pediatric hospitals in metropolitan Atlanta from 92 children that were immunocompromised and/or had a hospital acquired acute gastroenteritis. NoV was identified in 16.3% (15/92) of all stool specimens; 23.4% (11/47) in immunocompromised only children, and 13.3% (4/30) in children with HAI. All NoV positive cases were genogroup II (GII), and GII.4 was the predominant strain followed by GII.3, GII.12, and GII.13. The average NoV load for immunocompromised patients was 6.3 ± 1.4 log genome equivalent copies (GEC) per gram of stool compared to 5.8 ± 1.1 log GEC among patients with HAI. NoV infections are common among immunocompromised children and children with hospital-acquired gastroenteritis, underscoring the urgent need for rapid NoV detection system, and highlighting the importance of strict hospital hygiene practices. J. Med. Virol. © 2013 Wiley Periodicals, Inc.
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Article: Norovirus in healthcare settings.[Show abstract] [Hide abstract]
ABSTRACT: To provide an overview of the burden of norovirus disease in healthcare settings and the factors responsible for outbreaks in these institutions; to assess progress on interventions aimed at reducing the burden of norovirus disease.Current Opinion in Infectious Diseases 08/2014; · 5.03 Impact Factor
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ABSTRACT: Acute gastroenteritis caused by the noroviruses (NV) is often of 2-3 days duration and is characteristically self-limiting. In contrast, chronic infection caused by noroviruses in immunocompromised individuals can last from weeks to years, making clinical management difficult. The mechanisms by which noroviruses establish persistent infection, and the role of immunocompromised hosts as a reservoir for noroviruses in the general human population are not known. However, study of this patient cohort may lead to new insights into norovirus biology and approaches to treatment.This article is protected by copyright. All rights reserved.Clinical Microbiology and Infection 07/2014; · 4.58 Impact Factor