Article

Effectiveness of Green Tea in a Randomized Human Cohort: Relevance to Diabetes and Its Complications.

ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, Réduit, Mauritius.
BioMed research international 01/2013; 2013:412379. DOI: 10.1155/2013/412379
Source: PubMed

ABSTRACT Epidemiological studies have argued that green tea could mitigate diabetes and its complications. This study investigated the phytophenolic profile of Mauritian green tea and its antioxidant propensity. The effect of green tea on the risk factors: waist-hip ratio, glucose level, arterial pressure, antioxidant status, and alanine aminotransferase (ALT) in prediabetics was assessed. The experimental group consumed 3 cups of green tea daily for 14 weeks followed by a 2-week washout period. The control group followed a water regimen. Green tea contained high level of phenolics related to its antioxidant power. Green tea suppressed waist-hip ratio of women from a significant increase and suppressed mean arterial pressure of men and women from a significant decrease after week 14. It reduced ALT level in women by 13.0% (P < 0.1) while increasing the antioxidant potential of men and women sera by 2.7% (P < 0.1) and 5.1% (P < 0.1). The study timescale may have been too short to enable demonstration of effects on fasting plasma glucose and HbA1c outcomes. Green tea regimen could form part of a healthy lifestyle that might ameliorate features of metabolic syndrome and subsequent risks for diabetes and its complications. This trial is registered with ClinicalTrials.gov NCT01248143.

Full-text

Available from: Theeshan Bahorun, May 13, 2014
1 Follower
 · 
82 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Diabetes is a systemic disease affecting a large proportion of the population worldwide. Hyperglycemia, the major factor responsible for its development, is known to cause both microvascular and macrovascular complications if not controlled in time. Retinopathy is one such microvascular complication of the eye and has been studied extensively. There are biochemical pathways that lead to its progression and are common to other complications, viz. the formation of advanced glycation end products, the activation of protein kinase C, increase in oxidative stress and the polyol pathway. Though there are standard treatments available to manage diabetic retinopathy, there remains a need to explore herbal medicine as an alternative for its treatment. Many herbal preparations alleviating hyperglycemia that are used to treat dia-betes or have insulin sensitizing effects are available in the market. These may help managing diabetic retinopathy, too. Many plants are known to produce inhibitors of advanced glycation end products, the aldose reductase (polyol) pathway, and protein kinase C (PKC). Hence, there is a necessity to evaluate the potential of these plants, focussing on individual phytoconstituents like phenolic compounds.
    11/2014; 514(29):3-29. DOI:10.2174/2210290601405010029
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Consumers are very aware of contaminants that could pose potential health hazards. Most people drink tea as an infusion (adding hot water); however, in some countries, including India, China, and Egypt tea is drunk as a decoction (tea and water are boiled together). An infusion usually brings the soluble ingredients into solution; whereas a decoction brings all soluble and non-soluble constituents together. Therefore, a cup of tea may contain various kinds of contaminants. In this review, we focus on green and black tea, because they are most commonly consumed. Our target was to examine the transfer rate of contaminants (pesticides, environmental pollutants, mycotoxins, microorganisms, toxic heavy metals, radioactive isotopes (radionuclides), and plant growth regulators) from tea to infusion/brewing, factors contributing to the transfer potential and contaminants degradation, and residues in or on the spent leaves. We concluded that most contaminants leaching into tea infusion are not detected or are detected at a level lower than the regulatory limits.However, the traditional practice of over-boiling tea leaves should be discouraged, as there may be a chance for more transfer of contaminants from the tea to the brew.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 08/2014; 31(11). DOI:10.1080/19440049.2014.958575 · 2.34 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In recent years, there is growing evidence that polyphenols-rich natural products, like nutraceuticals and food supplements, may offer unique treatment modalities for various aspects of type 2 diabetes mellitus (T2DM), due to their biological properties. Therefore, research is now focused on potential efficacy of different types of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans and anthocyans. Animal and human studies showed that polyphenols modulate carbohydrate and lipid metabolism, decrease glycemia, atherogenic dyslipidemia and insulin resistance, improve adipose tissue metabolism, and modulate oxidative stress and inflammatory processes. It is relevant to understand the proper dose and duration of supplementation with polyphenols-rich extracts in order to guide effective therapeutic interventions in diabetic patients.
    Current Medicinal Chemistry 08/2014; 22(1). DOI:10.2174/0929867321666140826115422 · 3.72 Impact Factor