Article

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.
Immunity (Impact Factor: 19.75). 09/2012; 37(3):535–548. DOI: 10.1016/j.immuni.2012.06.015

ABSTRACT Graphical Abstract
Figure optionsView in workspace

Highlights
► Bile acid enzyme CYP7B1 is required for EBI2 ligand generation and B cell responses ► HSD3B7 inactivates EBI2 ligand and is required in stromal cells for gradient generation ► FDCs are required for EBI2-dependent B cell segregation in the follicle ► HSD3B7 restricts EBI2 ligand production by T zone dendritic cells

2 Followers
 · 
44 Views