Vitamin D: Non-skeletal actions and rational use

Serviço de Clínica Geral e Propedêutica, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brasil. Electronic address: .
Revista da Associação Médica Brasileira (Impact Factor: 0.93). 10/2013; 59(5). DOI: 10.1016/S2255-4823(13)70509-5
Source: PubMed


Recent years have witnessed a substantial increase in the number of seric determinations of vitamin D, in a worldwide basis. At Hospital das Clínicas of Faculdade de Medicina of Universidade de São Paulo that increase reached 700% over the last four years. Nevertheless there are many controversies on the literature about the role of vitamin D in conditions unrelated to the musculoskeletal system. In this study the metabolism, sources and actions of vitamin D on the body are reviewed. Observational studies, clinical trials, systematic reviews and metanalysis which focused on the relationship between the vitamin and conditions such as cancer, cardiovascular disease, diabetes and falls were searched on the literature, analyzed and discussed. Results are presented as quiz and answer, tables and a figure. The role of vitamin D on the above-mentioned conditions is discussed, and the controversial issues stressed.

Download full-text


Available from: Luiz Augusto Marcondes Fonseca, Aug 01, 2014
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction Nutritional rickets is an emergent disease in Spain, and occurs particularly in black and dark-skinned infants and children from immigrant populations. The aim of this work was to ascertain the vitamin D reserve in a population of native and immigrant children under the age of 6 years. Population and methods A prospective study was conducted at a Primary Healthcare Centre in Salt (Girona). Patients: 307 children with the following origin and race distribution: Caucasian (n = 85; 28%), Sub-Saharan (n = 101; 32.5%); Maghrebí (n = 87, 28.0%); Central-American (n = 20; 6.4%) and Indo-Pakistani (n = 14; 4.5%). The biochemistry blood parameters studied were: calcium, phosphorus, alkaline phosphatase, 25-hydroxivitamin D, and parathormone. A nutritional survey was used to estimate calcium and vitamin D intake and degree of sun exposure. Results Vitamin D deficiency (<20 ng/ml) was detected in Caucasians (8%), Sub-Saharans (18%), Central-Americans (20%), Maghrebís (34.5%), and Indo-Pakistanis (64%). Of the children studied (n = 9), 2.9% had serious vitamin D deficiency (< 10 ng/ml); only one child of Sub-Saharan origin met the biochemical criteria for classical rickets. The prevalence of vitamin D deficiency was significantly higher in children not receiving vitamin D supplements in the first year of life. Conclusions Plasma vitamin D concentrations were deficient in 22.5% of children under the age of six, being more prevalent in children of Indo-Pakistani and Maghrebí origin.
    Anales de Pediatría 07/2014; 142(5). DOI:10.1016/j.anpedi.2014.05.007 · 0.83 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This paper describes the electrochemical determination of vitamin D2 (ergocalciferol) and D3 (cholecalciferol) in mixed organic/water solvent, using a glassy carbon electrode (GCE). The mixing ratio of organic/water solvent has an important influence on the electrocatalytic response of D vitamins on the surface of the glassy carbon electrode. Well-defined peaks for Vitamin D2 and D3 were observed in a 40 % ethanol/60 % water solution with lithium perchlorate as the support electrolyte. This study demonstrated that the glassy carbon electrode is highly sensitive for the determination of vitamin D2 and D3, with a limit of detection of 0.13 and 0.118 µmol L−1, respectively. No significant interference was seen for vitamins A, E and K in the detection of vitamin D.
    Electroanalysis 12/2014; 26(12). DOI:10.1002/elan.201400451 · 2.14 Impact Factor