Article

Accumulation and Biodistribution of Gold Nanoparticles in the Mesenteric Lymph Nodes at Oral Administration

Russian Open Medical Journal 09/2013; 2(3):1-3.

ABSTRACT Abstract: The aim: to conduct analysis of the accumulation and biodistribution of gold nanoparticles in the structural and functional areas
of mesenteric lymph nodes of white rats conducted with regard to the size and duration of the oral administration. The methods of dark
field microscopy with Leica DM 2500 microscope were used to assess biodistribution of gold nanoparticle. The histochemical reaction of
silver amplification with silver lactate by Danscher was used to confirm its identification. Results: It was found that the gold nanoparticles
of 1‐3 nm were not detected by these methods in any of the areas of the lymph nodes regardless of the duration of administration, gold
nanoparticles of sizes 15 and 50 nm were detected in the form of clusters in the cytoplasm of macrophages and lymphocytes mainly in the
mantle zone of lymphoid follicles and brain strands. Conclusion: It was established that the gold nanoparticles of sizes 15 and 50 nm were
detected in the form of clusters in the cytoplasm of macrophages and lymphocytes

1 Bookmark
 · 
111 Views

Full-text

View
40 Downloads
Available from
May 20, 2014