Starvation favors glioma stem cells

Departments of Neurology, Pediatrics and Neurosurgery, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
Nature Neuroscience (Impact Factor: 16.1). 10/2013; 16(10):1359-61. DOI: 10.1038/nn.3524
Source: PubMed


High-grade glioblastomas survive glucose-poor environments by becoming more stem cell–like. Increased glucose uptake by the transporter Glut3, a new biomarker of poor clinical outcome, drives this enhanced malignant progression.

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