Non-apnea Sleep Disorder Increases the Risk of Periodontal Disease: A Retrospective Population-Based Cohort Study (Version 3).
ABSTRACT Aim: The aim of this study was to determine whether non-apnea sleep disorder patients with comorbidity have an increased risk of periodontal disease. Materials and Methods: Patients newly diagnosed with non-apnea sleep disorders (NA-SD) in 1997-2010 were identified as the study cohort from the Taiwan National Health Insurance (TNHI) database. For each NA-SD patient, two matched controls without sleep disorders were randomly selected for comparison. Results: The overall incidence rate ratio of severe periodontal diseases was 39% higher in the NA-SD cohort than in the without NA-SD cohort (7.93 vs. 5.69 per 1,000 person-years), with an adjusted HR of 1.36, (95% CIs = 1.30-1.43). The effect of NA-SD on the risk of severe periodontal diseases was higher in young patients, and middle-aged patients, as compared with patients over 65 years of age (≤ 35 years of age, HR = 1.13, 95% CIs = 1.04-1.24; 35-50 years of age, HR = 1.73, 95% CIs = 1.61-1.86; 50- 65 years of age, HR =1.69, 95% CI = 1.58-1.81). Conclusion: Non-apnea sleep disorder might increase the risk of periodontal disease.
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ABSTRACT: Background This study evaluated the relationship between sleep disorders (SDs) and osteoporosis risk in Taiwan. Methods From the Taiwan National Health Insurance data, we identified 44690 newly diagnosed SD patients (846 with apnea and 43844 without) from 1998 to 2001 and 89380 comparisons without SD in the same period frequency matched by sex, age and diagnosis year. Incident osteoporosis was measured by the end of 2010. Result Patients with apnea-SD and nonapnea SD exhibited a higher osteoporosis incidence rate than did the comparisons (9.97 and 13.3 vs. 6.77 per 1000 person-years, respectively). The Cox method estimated adjusted hazard ratio (HR) of osteoporosis was 2.98 (95% confidence interval [CI]: 2.36-3.74) in apnea-SD patients, compared with 2.76(95% CI; 2.64-2.88) in nonapnea-SD patients after controlling for sex, age, comorbidities, and treatment. Greater HRs of osteoporosis were observed for female patients (4.00, 95% CI = 3.72–4.29) and those aged > 64 years (42.0, 95% CI = 33.5–52.7) in the apnea SD sub-cohort. Apnea SD was associated with the highest risk of osteoporosis without fracture compared with both the nonapnea SD sub-cohort and comparisons. Conclusion Patients with sleep disorders have an elevated risk of osteoporosis, especially for women and the elderly.Sleep Medicine 08/2014; 15(11). DOI:10.1016/j.sleep.2014.07.005 · 3.10 Impact Factor