Review Article: Efficacy and Duration of Immunity after Yellow Fever Vaccination: Systematic Review on the Need for a Booster Every 10 Years

Universidad Peruana Cayetano Heredia, Lima, Peru.
The American journal of tropical medicine and hygiene (Impact Factor: 2.7). 09/2013; 89(3):434-44. DOI: 10.4269/ajtmh.13-0264
Source: PubMed


Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus-infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus-infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.

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    • "Pathogenesis of YF is not fully understood, and there is no approved specific antiviral therapy for YF (Julander, 2013; Woodson et al., 2013). The 17D vaccine has been used in the YF control programs in endemic areas as well as in travelers, and the vaccine elicits long-term immunity (Gotuzzo et al., 2013; Ishikawa et al., 2014; Patel and Simons, 2013). Rare adverse effects including YEL-AND and YEL-AVD have been reported (Breugelmans et al., 2013; Ishikawa et al., 2014). "
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  • Journal of Vaccines and Vaccination 12/2013; 04(08). DOI:10.4172/2157-7560.1000e122
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