Pulse Wave Velocity as Index of Arterial Stiffness in HIV-Infected Patients Compared With a Healthy Population

1Lluita contra la Sida Foundation, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Barcelona, Spain. 2Department of Econometrics, Statistics and Spanish Economy
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.56). 08/2013; 65(1). DOI: 10.1097/QAI.0b013e3182a97c17
Source: PubMed


Chronic HIV infection leads to premature atherosclerosis. Arterial stiffness is considered a subclinical marker of cardiovascular disease.
Pulse wave velocity (PWV) was determined in 254 individuals (174 HIV-infected patients and 80 healthy controls, 2:1 matched by age and gender), to compare the prevalence of arterial stiffness and to identify associated factors. PWV was determined using non-invasive automated device (Complior). Factors associated with impaired PWV were assessed among cardiovascular risk factors, HIV-infection parameters and laboratory data. Logistic regression analyses were performed to determine differences between groups and factors associated to arterial stiffness.
Overall, 81.4% of participants were male, median age was 46.54 (IQR 41, 52) years. Higher percentages of HIV-infected subjects showed dyslipemia (p=0.012) and smoking habit (p=0.002). The median time from HIV diagnosis was 13 (IQR 6, 18) years and the median time on antiretroviral therapy was 11 (IQR 5, 15) years. Nearly all patients were virologically suppressed (89.7%) at the time of PWV. Arterial stiffness in the global population was 20.5%, 18.9% in HIV-infected group and 23.8% in controls (p=0.405). High diastolic blood pressure and high levels of triglycerides at time of PWV were associated with increased PWV (p= 0.009 and p= 0.023, respectively).
Virologically suppressed HIV-infected patients showed similar arterial elasticity to non-HIV-infected patients. HIV-related conditions were not associated with arterial stiffness, probably because of the good immunological and virological status of this group. However, high diastolic pressure at the time of PWV and high levels of triglycerides were associated risk factors.

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