Discrete intramural sonolucency: A new echocardiographic finding in acute myocardial infarction

Harborview Medical Center, University of Washington, Seattle, Washington, USA
The American Journal of Cardiology (Impact Factor: 3.28). 02/1981; 47:404. DOI: 10.1016/0002-9149(81)90689-5
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    ABSTRACT: It is almost impossible to anticipate all of the potential technologic and clinical advances in echocardiography; however, the development of new clinical techniques, new instrumentation, stress echocardiography, new contrast agents, the ability to identify tissue types, improved ultrasonics information from the circulating blood. Doppler echocardiography, three dimensional echocardiography, the ability to obtained ultrasonic information using catheters or surgical exploration and especially improved techniques for quantitating echocardiographic data, make the potential usefulness of echocardiography in assessing cardiac function, and specifically left ventricular function, very exciting. We should be able to use the advances in echocardiography to improve our understanding of normal cardiac function and pathophysiology, as well as to enhance our ability to make precise diagnoses.
    The American Journal of Cardiology 05/1982; 49(5):1330-6. DOI:10.1016/0002-9149(82)90066-2 · 3.28 Impact Factor
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    ABSTRACT: Two dimensional echocardiography is potentially a more accurate and reliable method for assessing ventricular function than the standard M mode echocardiographic technique. More widespread clinical application of this technique for the quantitative assessment of left ventricular systolic function has been limited by the fact that quantitation was very time-consuming. Recent advances in two dimensional instrumentation allow quantitation to be performed with less difficulty and in a shorter time period. As a result, two dimensional echocardiography should find widespread clinical use in the evaluation of global and segmental ventricular function.
    The American Journal of Cardiology 05/1982; 49(5):1319-23. DOI:10.1016/0002-9149(82)90064-9 · 3.28 Impact Factor
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    ABSTRACT: We hypothesized that acute myocardial infarction could be detected in standard two-dimensional echocardiograms of closed-chest dogs by evaluating regional echo amplitude distributions using computerized image analysis. We tested this hypothesis by performing standard, 2.4 MHz two-dimensional echoes before and 2 days after circumflex coronary occlusion in seven closed-chest dogs. Control and infarcted regions of interest were studied in digitized stop-frame images. Average gray level was calculated for each region of interest, and the shape of the gray-level distribution was analyzed by calculation of skewness and kurtosis and by qualitative features of shape. Average gray level increased significantly from the pre- to postocclusion images in the infarcted regions (16.7 +/- 4.2 vs. 32.4 +/- 4.4 units, P less than 0.01), but not in the control regions (17.4 +/- 4 vs. 22.3 +/- 5.5., P = NS). Average gray level could not distinguish between infarcted and normal regions within the postocclusion images (36 +/- 5.2 vs. 33.6 +/- 5.8, P = NS). Three independent observers qualitatively evaluated histogram shape and correctly identified 7/7 MI regions (100% sensitivity) and 14/20 normal regions (70% specificity). Quantitatively, infarct regions exhibited a significant decrease in kurtosis from pre- to postocclusion images (7.1 +/- 4.0 vs. 5.2 +/- 2.9, P = NS). Within postocclusion images, infarcted regions displayed a significantly lower kurtosis than did normal regions (0.27 +/- .47 vs. 2.5 +/- 1.0, P less than .01). We conclude that acute myocardial infarction may be detected in closed-chest dogs by analyzing regional echo amplitude data from standard two-dimensional echocardiograms.
    Circulation Research 02/1983; 52(1):36-44. DOI:10.1161/01.RES.52.1.36 · 11.02 Impact Factor
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