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Fulerenol – właściwości i zastosowanie w naukach biomedycznych

ABSTRACT Fullerenols, the water-soluble derivatives of fullerenes, are currently being recently intensively studied in the context of the possibility of their application in the biomedicine. Due to their hydrophilic properties and the ability to eliminate free radicals, fullerenols may in the future provide a solid alternative to currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases and radiobiology. Depending on the research protocol
applied, fullerenols may also act as pro oxidants. The dualistic nature of fullerenols may
contribute to finding new biomedical applications of these agents in the future, by exerting
a cytotoxic or protective effect respectively against cancer cells or healthy cells. Because of
the encapsulated structure of fullerenols, there exists the possibility of their application in
medical diagnostics in the transfer of contrast agents or in the drug transport.
During the planning of an experiment designed to investigate the effects of radiation in
combination with derivatives of water-soluble fullerenes, the possibility of appearance of the
“dose-response effect” should be taken into consideration since it significantly contributes to
one of the two possible effects: protection or sensitization. The same applies to the possibility
of using these compounds as potential neuroprotectors. Fullerenol may protect neurons in
the particular areas of the brain but in the definedcertain doses it may also induce cell death.
A giant leap in the field of nanotechnology not only leads scientists to search for new applications
of nanomaterials such as fullerenols, but also raises the question about their harmful
effect on the environment. High utilization of hardly biodegradable fullerenols increases the
likelihood of their accidental release into natural systems and their bioaccumulation.
Despite convincing evidences about the potential applications of fullerenols in biomedicine,
we still have insufficient knowledge about the mechanism of action of these molecules and
their possible side effects.

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May 21, 2014