Divergent Astrovirus Associated with Neurologic Disease in Cattle

Emerging Infectious Diseases (Impact Factor: 6.75). 09/2013; 19(9):1385-92. DOI: 10.3201/eid1909.130682
Source: PubMed


Using viral metagenomics of brain tissue from a young adult crossbreed steer with acute onset of neurologic disease, we sequenced the complete genome of a novel astrovirus (BoAstV-NeuroS1) that was phylogenetically related to an ovine astrovirus. In a retrospective analysis of 32 cases of bovine encephalitides of unknown etiology, 3 other infected animals were detected by using PCR and in situ hybridization for viral RNA. Viral RNA was restricted to the nervous system and detected in the cytoplasm of affected neurons within the spinal cord, brainstem, and cerebellum. Microscopically, the lesions were of widespread neuronal necrosis, microgliosis, and perivascular cuffing preferentially distributed in gray matter and most severe in the cerebellum and brainstem, with increasing intensity caudally down the spinal cord. These results suggest that infection with BoAstV-NeuroS1 is a potential cause of neurologic disease in cattle.

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Available from: Eric Delwart, Sep 22, 2014
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    • "Mamastrovirus 9 (strain HAstV-PS) was also identified as the causative agent in a fatal case of encephalitis in a child with agammaglobulinemia [20] and HAstV-MLB2 (whose capsid is 74% identical to mamastrovirus 6 strain MLB1 and may therefore also qualify as a distinct species) has also been reported in the plasma of a febrile child [21]. Astroviruses were also found in the brain of minks with a shaking symptoms [22] and in the brain and spinal cord of cows with neurologic symptoms [23] indicating that astroviruses are not exclusively enteric infections but can also affect other organ systems. Varied astroviruses have also been detected in feces from a wide variety of farm, wild, and laboratory aminals [11] indicating that the known diversity of this viral family is likely to continue its rapid expansion. "
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