Carbon nanotubes in hyperthermia therapy

Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem NC 27157.
Advanced drug delivery reviews (Impact Factor: 15.04). 08/2013; 65(15). DOI: 10.1016/j.addr.2013.08.001
Source: PubMed


Thermal tumor ablation therapies are being developed with a variety of nanomaterials, including single- and multiwalled carbon nanotubes. Carbon nanotubes (CNTs) have attracted interest due to their potential for simultaneous imaging and therapy. In this review, we highlight in vivo applications of carbon nanotube-mediated thermal therapy (CNMTT) and examine the rationale for use of this treatment in recurrent tumors or those resistant to conventional cancer therapies. Additionally, we discuss strategies to localize and enhance the cancer selectivity of this treatment and briefly examine issues relating the toxicity and long term fate of CNTs.

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Available from: Ravi Singh, Jun 17, 2015
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    • "Their ability as photothermal agents depends on their absorption efficiency at the wavelength of excitation. Carbon nanotubes (CNTs) and other carbon-based materials generate heat under illumination in a wide spectral range [11]. This is an advantage over gold nanostructures whose plasmon resonance is peaked at wavelengths that vary with the biological environment. "

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    • "In addition to trigger the drug release, a local heating may be itself cytotoxic (e.g. hyperthermia and thermal ablation therapies) [18] [19] [20], thus synergically boosting the effect of the drug. Furthermore, it has been reported that a temperature rise can favor the extravascular accumulation of the drug due to an increase of the vascular permeability [8]. "
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