Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits

Handbook of Behavioral Neuroscience 01/2010; 20:501-525. DOI: 10.1016/B978-0-12-374767-9.00029-9
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    ABSTRACT: The luteinizing hormone-releasing hormone (LHRH) systems of rat olfactory bulbs and nasal areas were studied in neonatal and adult rats. Animals were perfused with Zamboni's fixative and olfactory bulbs with nasal olfactory areas intact were removed, postfixed, and decalcified. LHRH was immunohistochemically demonstrated in unembedded frozen or vibratome sections.Luteinizinghormone-releasinghormoneimmunoreactive elements were found along the course of the nervus terminalis (NT) and within both the main and accessory olfactory bulbs (MOB and AOB, respectively). Both LHRH neurons and fibers were present in the AOB, but only fibers were detected in the MOB. The fibers of the AOB were not confined to any particular lamina while fibers in the MOB were found mainly in the external plexi-form layer. LHRH fibers were found in the mucosa of the olfactory epithelium of the vomeronasal organ in both neonatal and adult rats.The NT probably serves as a source of LHRH fibers for both the AOB and the MOB and for fibers observed in the olfactory epithelium of the vomeronasal organ. Other likely sources of LHRH fibers in the olfactory bulb are discussed.
    The Journal of Comparative Neurology 08/1983; 218(4):426 - 432. · 3.66 Impact Factor
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    ABSTRACT: The involvement of the nervus terminalis in lordosis, induced by manual tactile stimulation, was investigated in the female hamster. Lordosis latencies were measured in response to manual lumbosacral tactile stimulation, which was performed at 5 different delay times after the previous lordotic response. Nervus terminalis lesion (TNX), control forebrain lesion (FBX), and sham (SH) surgeries were performed after preoperative data was collected, and animals were tested again postoperatively. Latencies to lordose were compared separately for each delay time between preoperative and postoperative tests. The TNX group showed small, but significant, decreases in lordosis latencies postoperatively. Lordosis latencies for the SH and FBX groups did not change. These results suggest that the nervus terminalis plays a minor role in mediating sensory processing during reproductive encounters.
    Physiology & Behavior 07/1997; 61(6):867-71. · 3.16 Impact Factor
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    ABSTRACT: The terminal nerve is composed of a morphologically heterogeneous population of unipolar, bipolar and multipolar neurons located in the nasal and intracranial cavities of vertebrates. The question has arisen as to whether these neurons are neurochemically heterogeneous and therefore possibly functionally different as well. Among the substances localized in the terminal nerve are acetylcholinesterase and luteinizing hormone-releasing hormone-like immunoreactive material. We have developed a double-label procedure, combining immunocytochemistry and enzyme histochemistry to determine whether these two substances are localized within different populations of terminal nerve neurons. Compatibility of the two procedures was accomplished by modifications of the fixative and primary antibody solutions. In the immunocytochemical step, the avidin-biotin-peroxidase complex coupled to a new chromogen, Chromo-red, produced a bright red reaction product in neurons containing luteinizing hormone-releasing hormone-like material. This reaction product was easily differentiated from the black silver-intensified acetylcholinesterase label. In both neonatal and adult preparations, a large population of terminal neurons contained the acetylcholinesterase label only, whereas a smaller population contained both acetylcholinesterase and luteinizing hormone-releasing hormone-like material. The acetylcholinesterase-containing population of neurons was concentrated peripherally and included multipolar neurons. In contrast neurons with the two substances co-localized were unipolar or bipolar and were concentrated centrally. The simultaneous visualization of acetylcholinesterase and luteinizing hormone-releasing hormone-like material in the same tissue section enable the differentiation of two separate neurochemically defined populations of terminal neurons. The distribution of these two neuronal types was the same in neonatal and adult animals. These data provide support for a functional diversity of terminal neurons.
    Neuroscience 12/1986; 19(3):719-40. · 3.12 Impact Factor


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May 15, 2014