Bacterial antimicrobial efflux pumps of the MFS and MATE transporter families: A review

In book: Recent Research Developments in Antimicrobial Agents & Chemotherapy, Chapter: Bacterial antimicrobial efflux pumps of the MFS and MATE transporter families: A review., Publisher: Research Signpost, Inc., Editors: Shankar Pandali, pp.1-21


Bacteria are causative agents of human infectious
disease and are a serious public health concern due to drug and
multi-drug resistance determinants that reduce the clinical efficacy
of antimicrobial agents. Among the variety of antimicrobial
resistance mechanisms, drug and multi-drug efflux pumps
represent a significant cause of chemotherapeutic failure in the
treatment efforts of bacterial infectious disease. This chapter deals
mainly with bacterial drug and multi-drug efflux pump systems of
the major facilitator superfamily (MFS) and multi-drug and toxic
compound extrusion (MATE) family. Studies of these bacterial
anti-bacterial drug efflux systems will help our understanding of
their molecular mechanisms and may help reduce the conditions
that foster multi-drug resistance.

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    • "We observed the repression of genes encoding ABC membrane transporters involved in multidrug resistance (MDR) pumps, such as MatE and MdtK which belong to the MATE-family transporters for multidrug and toxic compound extrusion (Omote et al. 2006), and also the repression of genes encoding transporters from the major facilitator superfamily (MFS) (Lubelski et al. 2007; Kumar et al. 2013). MDR pumps are capable of extruding heavy metals (Silver and Phung 2005; Martínez et al. 2009). "
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