Microwave versus ultrasound assisted synthesis of some new heterocycles based on pyrazolone moiety

Journal of Saudi Chemical Society (Impact Factor: 2.52). 07/2010; 14(3):287-299. DOI: 10.1016/j.jscs.2010.02.010


Different pyrazolone derivatives were prepared by microwave irradiation and ultrasound assisted methods besides the traditional ones. They were used for synthesis of some derivatives of spiropiperidine-4,4′-pyrano[2,3-c]pyrazole, dihydropyrano[2,3-c]pyrazole, pyrazole-4-carbothioamide, 4-(2-oxo-1,2-diphenylethylidene)-1H-pyrazol-5(4H)-one, azopyrazole, arylmethylenebis-1H-pyrazol-5-ol and araylidene-1H-pyrazol-5(4H)-one via reactions with different reagents applying the ultrasound method in some cases.

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    Green Chemistry - Environmentally Benign Approaches, 02/2012; , ISBN: 978-953-51-0334-9
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    ABSTRACT: Considerable amount of research has been carried out in the field of pyrazolone derivatives due to their diverse biological, pharmacological and chemical properties. The need was felt to synthesize certain 3-methyl-5-pyrazolone derivatives with potent analgesic and anti-inflammatory activity and with lesser side effects as it had been proved of late that the beneficial effects of pyrazolones outweigh its adverse effects. The present work involved the synthesis of some aryl 3-methyl-5-pyrazolone derivatives by Knorr-Pyrazolone condensation followed by subsequent one step Knovenagel-Michael condensation and the evaluation of the analgesic and anti-inflammatory activities of the synthesized compounds using Acetic acid writhing method in Swiss Albino mice and Carageenan induced rat paw edema in Wistar rat respectively.
    International Journal of Pharmacy and Pharmaceutical Sciences 11/2012; 5(1). · 1.59 Impact Factor
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    ABSTRACT: In the recent years, microwave (MW) radiation is widely used as a source of heating in organic synthesis. Since the discovery of the MW heating approach, MW-assisted reaction has emerged as a new green-method in organic synthesis as it provides spectacular accelerations, higher yields under milder reaction conditions, and higher product purities, and it reduces pollution of the environment through the use of solvent-free reaction protocols. N-containing heterocycles hold a special place among pharmaceutically significant natural products and synthetic compounds needed for any developed human society. Therefore, organic chemists have been engaged in extensive efforts to produce these compounds following various greener techniques, primarily to circumvent growing environmental concerns. In this review, we discuss only the MW-assisted synthesis of N-containing heterocyclic compounds.
    Green Chemistry Letters and Reviews 06/2013; 6(2). DOI:10.1080/17518253.2012.733032 · 1.33 Impact Factor
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