Metodología del estudio de cohortes del proyecto ITINERE sobre consumidores de heroína en tres ciudades españolas y características básicas de los participantes

Revista Espanola De Salud Publica - REV ESP SALUD PUBLICA 01/2005; 79(4). DOI: 10.1590/S1135-57272005000400005
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    ABSTRACT: This article reports on the ethnographical study carried out among an opiate consumer community in Barcelona (Spain) and analyses the meanings that those consumers build and handle around the substances that they consume. Our approach emphasises the point of view of the consumers in their understanding of drugs and the type of relationships that they maintain between themselves and with their social environment.
    Addiction Research and Theory 07/2009; 16(5):434-452. DOI:10.1080/16066350802041455 · 1.03 Impact Factor
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    ABSTRACT: This work describes the first analytical method specifically developed for the multianalyte determination of several drugs of abuse and their metabolites in air. The methodology is based on pressurized liquid extraction (PLE) of atmospheric particles collected by means of high volume sampler equipped with quartz microfiber filters and subsequent analysis of the extracts by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Up to 17 different compounds belonging to five different chemical classes (cocainics, amphetamine-like compounds, opioids, cannabinoids, and lysergic compounds) are determined by means of this methodology. Acquisition is performed in the selected reaction monitoring (SRM) mode recording two transitions per compound (except for amphetamine). Quantitation by the internal standard method is based on the use of surrogated deuterated standards. The method has been validated in terms of linearity, accuracy, repeatability and sensitivity with satisfactory results. Absolute recoveries were above 50% for most investigated compounds. Method precision showed relative standard deviations (RSD) below 13% for all compounds, except for cannabinoids. The method limits of determination ranged from 0.35 pg/m(3) (for 2-oxo-3-hydroxy-LSD) to 22.55 pg/m(3) (for 11-nor-9 carboxy THC). Finally, as a part of the method validation, the optimized procedure was applied to the analysis of ambient air samples (fine grain-size particulates, PM(2.5)) collected at two urban background sites in Barcelona and Madrid (Spain). Results evidenced the presence of cocaine, benzoilecgonine, tetrahydrocannabinol, ecstasy, amphetamine, methamphetamine, and heroin in some or all of the samples investigated. The highest mean daily levels corresponded to cocaine (850 pg/m(3)) followed by heroin (143 pg/m(3)).
    Analytical Chemistry 06/2009; 81(11):4382-8. DOI:10.1021/ac9002485 · 5.83 Impact Factor
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    ABSTRACT: Health Related Quality of Life (HRQL) of opiate users has been studied in treatment settings, where assistance for drug use was sought. In this study we ascertain factors related to HRQL of young opiate users recruited outside treatment facilities, considering both genders separately. Current opiate users (18-30 y) were recruited in outdoor settings in three Spanish cities (Barcelona, Madrid, Seville). Standardised laptop interviews included socio-demographic data, drug use patterns, health related issues, the Severity of Dependence Scale (SDS) and the Nottingham Health Profile (NHP). A total of 991 subjects (73% males), mean age = 25.7 years were interviewed. The mean global NHP score differed by gender (women: 41.2 (sd:23.8); men:34.1(sd:23.6);p < 0.05). Multivariate analysis was implemented separately by gender, variables independently related with global NHP score, both for males and females, were heroin and cocaine SDS scores. For women, only other drug related variables (alcohol intake and length of cocaine use) were independently associated with their HRQL. HIV+ males who suffered an opiate overdose or had psychiatric care in the last 12 months perceived their health as poorer, while those who had ever been in methadone treatment in the last 12 months perceived it as better. The model with both genders showed all factors for males plus quantity of alcohol and an interaction between gender and HIV status. Heroin users were found to be at a considerable risk of impaired HRQL, even in these young ages. A score approaching severity of dependence was the factor with the strongest relation with it.
    Health and Quality of Life Outcomes 12/2010; 8:145. DOI:10.1186/1477-7525-8-145 · 2.10 Impact Factor