Association of circulating sTRAIL and high-sensitivity CRP with diabetic nephropathy and foot ulcers

ABSTRACT Aim: Hyperglycemia is among the potent factors that may induce or facilitate apoptosis. TNF-Related Apoptosis-Inducing Factor (TRAIL) is known for its apoptotic and immunomodulatory effects that has recently been correlated to diabetes. We examined serum soluble TRAIL (sTRAIL) and high-sensitivity CRP (hs-CRP) levels and their association with various distinct parameters in type 2 diabetic nephropathy patients with diabetic foot disease.
Methods: Twenty-two diabetic nephropathy patients with foot ulcers were enrolled in our study. Patients had been diagnosed with diabetes at 24±10.58 years. Circulating sTRAIL and Hs-CRP levels were compared with control values, and possible correlations were investigated with parameters such as age, Wagner’s Grade (WG), BMI, HbA1c, and creatinine.
Results: Serum sTRAIL levels were significantly reduced in the patient group, compared to healthy subjects. High HsCRP levels correlated with age, and WGS correlated with BMI and creatinine levels.
Conclusion: Significantly suppressed sTRAIL levels in diabetic nephropathy patients with foot ulcers compared to healthy controls may suggest a protective role for TRAIL in the disease setting.

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