Recent evidence suggests that daily aspirin use decreases cancer risk, particularly for colorectal cancer, but evidence for alternate-day use is scant.
To examine the association between long-term, alternate-day, low-dose aspirin and cancer in healthy women.
Observational follow-up of a randomized trial.
Female health professionals.
39 876 women aged 45 years or older in the Women's Health Study (ClinicalTrials.gov: NCT00000479), 33 682 of whom continued observational follow-up.
100 mg of alternate-day aspirin or placebo through March 2004, with a median 10-year follow-up. Posttrial follow-up continued through March 2012.
A total of 5071 cancer cases (including 2070 breast, 451 colorectal, and 431 lung cancer cases) and 1391 cancer deaths were confirmed. Over the entire follow-up, aspirin had no association with total (hazard ratio [HR], 0.97 [95% CI, 0.92 to 1.03]; P = 0.31), breast (HR, 0.98 [CI, 0.90 to 1.07]; P = 0.65), or lung (HR, 1.04 [CI, 0.86 to 1.26]; P = 0.67) cancer. Colorectal cancer was reduced in the aspirin group (HR, 0.80 [CI, 0.67 to 0.97]; P = 0.021), primarily for proximal colon cancer (HR, 0.73 [CI, 0.55 to 0.95]; P = 0.022). The difference emerged after 10 years, with a posttrial reduction of 42% (HR, 0.58 [CI, 0.42 to 0.80]; P < 0.001). There was no extended effect on cancer deaths or colorectal polyps. More gastrointestinal bleeding (HR, 1.14 [CI, 1.06 to 1.22]; P < 0.001) and peptic ulcers (HR, 1.17 [CI, 1.09 to 1.27]; P < 0.001) occurred in the aspirin group.
Not all women received extended follow-up, and posttrial ascertainment bias cannot be ruled out. Gastrointestinal bleeding, peptic ulcers, and polyps were self-reported during extended follow-up.
Long-term use of alternate-day, low-dose aspirin may reduce risk for colorectal cancer in healthy women.
National Institutes of Health.
Available from: Muhammad Waqas Muhammad Usman Hingoro
"The strongest evidence for the use of aspirin in cancer prevention thus far lies in the data concerning aspirin's potential protective effects against colon cancer. Regular use of adult-strength (375 mg) aspirin was associated with a 20% statistically significant reduced risk of colorectal cancer , and taking low-dose aspirin every other day also appears to have a lesser protective effect against colon cancer . However, the use of low-dose aspirin following the diagnosis of colorectal cancer does not improve the overall survival rate . "
"The nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin are widely used to prevent and manage cardiovascular diseases, due to its antithrombotic as well as anti-inflammatory properties  . Recent studies suggest that NSAIDs may also contribute to beneficial effects against cancers of the gastrointestinal system, further broadening the potential for anti-inflammatory therapies . However, the presence of well-known side effects such as gastric bleeding and ulceration preclude the long-term use of NSAIDs for a large part of the population. "
[Show abstract][Hide abstract] ABSTRACT: Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions. Bioactive peptides derived from food proteins have been evaluated for various beneficial effects, including anti-inflammatory and antioxidant properties. In this review, we summarize the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.
BioMed Research International 01/2014; 2014:608979. DOI:10.1155/2014/608979 · 3.17 Impact Factor
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