Recent Expansions in an Emergent Novel Drug Delivery Technology: Emulgel.

Rungta College of Pharmaceutical Sciences and Research, Kohka- Kurud Road, Bhilai, Chhattisgarh, India. Electronic address: .
Journal of Controlled Release (Impact Factor: 7.71). 07/2013; 171(2). DOI: 10.1016/j.jconrel.2013.06.030
Source: PubMed


Emulgel is an emerging topical drug delivery system to which if more effort is paid towards its formulation & development with more number of topically effective drugs it will prove a boon for derma care & cosmetology. Emulgels are either emulsion of oil in water or water in oil type, which is gelled by mixing it with gelling agent. Incorporation of emulsion into gel increases its stability & makes it a dual control release system. Due to lack of excess oily bases & insoluble excipients, it shows better drug release as compared to other topical drug delivery system. Presence of gel phase makes it a non greasy & favors good patient compliance. These reviews gives knowledge about Emulgel including its properties, advantages, formulation considerations, and its recent advances in research field. All factors such as selection of gelling agent, oil agent, emulsifiers influencing the stability and efficacy of Emulgel are discussed. All justifications are described in accordance with the research work carried out by various scientists. These brief reviews on formulation method has been included. Current researched that work carried out on Emulgel are also discussed and highlighted the wide utility of Emulgel in topical drug delivery system. After the vast study, it can be concluded that the Emulgels appear better & effective drug delivery system as compared to other topical drug delivery system. The comprehensive analysis of rheological and release properties will provide an insight into the potential usage of Emulgel formulation as drug delivery system.

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    • "The gelation rate of emulsions and the characteristics of the obtained emulgels were studied. Emulgels are emulsion systems at which the continuous aqueous phase is gelled (Alexander et al., 2013) enjoying of the functional advantages of both hydrogels and emulsions. These dispersions are effective controlled-release delivery systems for bioactives including poorly water-soluble compounds (Yang, Liu, & Tang, 2013a, 2013b). "

    Carbohydrate Polymers 09/2015; DOI:10.1016/j.carbpol.2015.09.100 · 4.07 Impact Factor
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    • "Its similarity to sebum composition , the presence of oleic acid that acts as a skin softener and the presence of antioxidant components, such as vitamins A and E, make it extremely active in skin protection and regeneration (Varka and Karapantsios 2011; Viola and Viola 2009). Finally, a common non-ionic surfactant, i.e. Tween 60, also used for cosmetic systems and emulsion gels (Ajazuddin et al. 2013) was adopted in emulsion preparation. "
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    ABSTRACT: The advances in knowledge about production and stability of dispersed systems enable the development of differentiated vehicles such as nanoemulsions and nanoemulgels, which have been effectively used to increase the bioavailability and improve the stability of the active ingredients. Nowadays there is an intensely usage of natural bioactive materials as medicinal agent in pharmaceutical industries. Swietenia macrophylla oil is used due to the bioactivity of different parts of the plant as anti-inflammatory, anti-mutagenicity, anti-tumor. SM oil Nanoemulgels were prepared by incorporating nanoemulsion with hydrogel. First by preparing mixtures of oil, glycerol with sucrose ester (Laurate, Oleate and Palmitate) to produce pre-nanoemulsion using phase inversion technique, then nanoemulsion was produced using self-emulsification technique. After that, hydrogel was added to nanoemulsion to produce nanoemulgel. It was found that 50% oil with sucrose laurate 20% and 30% glycerol was able to produce pre-nanoemulsion, and then it was diluted with water under gentile agitation to produce nanoemulsion with droplets size 114 nm, low size distribution 0.163 and low zeta potential -43.1 mV. The optimal nanoemulsion formulation was mixed with different grades of hydrogel Carbopol 934 and 940 to produce nanoemulgels. It was found that Carbopol showed no influence on the oil droplets size with a range from 113 to 117 nm, size distribution from 0.155 to 0.163 and zeta potential range from -43.4 to -44.6 mV. In addition, it was able to produce a stable nanoemulgel at different temperatures 4°C, 25°C and 40°C when stored for one year and showed priority as thickening agent in relation to texture and rheological properties when compared to Carbopol 934. The anti-inflammatory test using carrageen an induced rat paw edema method for Swietenia macrophylla oil was carried and it was found that the inflammation inhibition of SM oil was higher for nanoemulgel compared to oil solution.
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