Emulgel is an emerging topical drug delivery system to which if more effort is paid towards its formulation & development with more number of topically effective drugs it will prove a boon for derma care & cosmetology. Emulgels are either emulsion of oil in water or water in oil type, which is gelled by mixing it with gelling agent. Incorporation of emulsion into gel increases its stability & makes it a dual control release system. Due to lack of excess oily bases & insoluble excipients, it shows better drug release as compared to other topical drug delivery system. Presence of gel phase makes it a non greasy & favors good patient compliance. These reviews gives knowledge about Emulgel including its properties, advantages, formulation considerations, and its recent advances in research field. All factors such as selection of gelling agent, oil agent, emulsifiers influencing the stability and efficacy of Emulgel are discussed. All justifications are described in accordance with the research work carried out by various scientists. These brief reviews on formulation method has been included. Current researched that work carried out on Emulgel are also discussed and highlighted the wide utility of Emulgel in topical drug delivery system. After the vast study, it can be concluded that the Emulgels appear better & effective drug delivery system as compared to other topical drug delivery system. The comprehensive analysis of rheological and release properties will provide an insight into the potential usage of Emulgel formulation as drug delivery system.
"Its similarity to sebum composition , the presence of oleic acid that acts as a skin softener and the presence of antioxidant components, such as vitamins A and E, make it extremely active in skin protection and regeneration (Varka and Karapantsios 2011; Viola and Viola 2009). Finally, a common non-ionic surfactant, i.e. Tween 60, also used for cosmetic systems and emulsion gels (Ajazuddin et al. 2013) was adopted in emulsion preparation. "
[Show abstract][Hide abstract] ABSTRACT: Emulsion gels are structured emulsions suitable for different uses for their specific behaviour, which is strongly dependent on the characteristics of the gelled dispersing phase. Therefore, it is important to adopt the specific gelling agent to tune the final emulsion rheological behaviour properly. Pectin is extremely interesting among potential hydrophilic gelling agents owing to its specific characteristics. In the present work, four different low-methoxyl pectins were adopted to prepare gels to be used as the dispersing phase in cosmetic or pharmaceutical emulsion gels. The rheological characterisation of pectin gels, prepared at room temperature to avoid the damage to potential thermolabile components, was carried out with small amplitude oscillations. The obtained gels were used, together with a common non-ionic surfactant (Tween 60), to prepare olive oil emulsion gels suitable to design new cosmetic products. A simple empirical model, proposed to relate the emulsion complex modulus to the oil fraction and properties of the dispersing phase, has shown itself to be a potentially useful tool to design formulations with desired properties.
[Show abstract][Hide abstract] ABSTRACT: Topical glucocorticoids (TG) such as dexamethasone (DEX) have been used for decades for the treatment of skin diseases. However, TG present well-documented side effects and their delivery to the skin is often insufficient. Therefore, many efforts have been undergone to improve the amount of drug delivered to the skin and to reduce side effects at the same time. In this work, the feasibility of DEX-submicron polymeric particles (SP) prepared by vibrational spray-drying as an approach to overcome the challenges associated with the topical administration of this drug class was evaluated. DEX was homogeneously dispersed in the SP matrix, according to confocal Raman microscopy analysis. Drug-loaded SP were incorporated into the oil phase of oil-in-water emulsions (creams). The formulation containing polymeric submicron particles (C-SP) showed controlled drug release kinetics and a significant drug accumulation in skin compared to formulations containing non-polymeric particles or free drug. DEX accumulation in the stratum corneum was evaluated by tape stripping and a depot effect over time was observed for C-SP, while the formulation containing the free drug showed a decrease over time. Similarly, C-SP presented higher drug retention in epidermis and dermis in skin penetration studies performed on pig skin in Franz diffusion cells, while drug permeation into the receptor compartment was negligible. It was demonstrated, for the first time, the advantageous application of submicron polymeric particles obtained by vibrational spray-drying in semisolid formulations for cutaneous administration to overcome challenges related to the therapy with TG such as DEX.
European Journal of Pharmaceutics and Biopharmaceutics 07/2014; 88(3). DOI:10.1016/j.ejpb.2014.07.008 · 3.38 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of API in it. So API has high solubility and oil may also have more or less pharmacological property, so may assist therapeutic action of API. Due to oil portion was present; it leads to more penetration of API in skin. Oil Micelle Size was less than 500 nm which provides more area for absorption of API in skin so more penetration and more effective than micro-emulsion. Microemulgel has advantage of emulgel that has dual benefits of micro-emulsion and gel and several the other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication and termination of medications will be easy etc.
Saudi Pharmaceutical Journal 08/2014; 39. DOI:10.1016/j.jsps.2014.08.002 · 1.28 Impact Factor
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