Bases moléculaires de la pathogénicité des Salmonella

Médecine et Maladies Infectieuses (Impact Factor: 0.91). 03/1992; 22:310-324. DOI: 10.1016/S0399-077X(05)80136-2

ABSTRACT In order to establish a successful infection, Salmonella must colonize host membranes, adhere to and invade epithelial cells, survive and even multiply in the reticuloendothelial system, produce tissue damages, and resist to host defence. Salmonella expresses virulence factors to fulfill these requirements. In S. typhi, the agent of human typhoid fever, all these factors are encoded by chromosomal genes. In S. typhimurium, the agent of murine typhoid fever, virulence factors are encoded by both chromosomal and plasmid genes. These factors, their functions and the genes involved in their synthesis and expression are covered in this review.

  • [Show abstract] [Hide abstract]
    ABSTRACT: A clinical collaborative study was conducted to compare two new chromogenic agar media, Rambach agar and the Salmonella Detection and Identification Medium (SMID) (bioMérieux, France), with two conventional media, Salmonella-Shigella agar and Hektoen agar. Thirty-nine Salmonella strains involving 14 serotypes were isolated from 1,454 stool specimens. After enrichment in a selective broth, 100% sensitivity was obtained with each medium. The SMID and Rambach agars are considerably more specific than the conventional media. Although SMID agar detects all Salmonella serotypes, it is not as specific as Rambach agar, which requires a complementary test (C8 esterase test) to detect all serotypes.
    European Journal of Clinical Microbiology 04/1994; 13(3):257-61. · 2.54 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This descriptive epidemiological study is based on 308 cases (139 women and 169 men) and 317 Salmonella strainsisolated during 39 months. An average of 95 Salmonella were isolated each year in the microbiology laboratory of the Guadeloupe University Hospital (total population: 407,000). The patients in this study were mostly young; 29.2% were under 1 year, 27.3% between 2 and 10, and 70 to 75% were under 30 years of age. The sex ratio was 1.22. No significant difference in the number of the isolates was noticed, even though an increase of Salmonella strains is described during the months of June, July and September. The most frequently isolated Salmonella serotypes were: S. enteritidis (40.1%), S. panama (15.5%), and S. typhimurium (9.8%). S. panama caused an unexpected infectious problem in the archipelago. In the same way, S. cerro and S. Kisangani were more frequently isolated in this study than in any other. Stool examination was the most common for Salmonella diagnosis, furthermore bacteremia rate (19.6%) and positive cerebrospinal fluid (CSF) culture (5/317) were among the most important ever reported.
    Medecine Et Maladies Infectieuses - MED MAL INFEC. 01/1998; 28(5):418-422.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Case study – In Burkina Faso, Salmonella infections are endemic with a typical peak during the warm rainy season (May–October). We report 11 cases of Salmonella meningitis observed at the National Hospital of Ouagadougou (Burkina Faso). Clinical diagnosis was based on examination of patients and CSF after lumbar puncture. CSF cytology and bacteriology were performed and bacterial isolates were identified by their morphology, their culture and biochemical features. An antibiogram by gel diffusion (Kirby Bauer) was made for each isolate. Ten of the 11 patients died within 24 h after admission. This study underlines the need for urgent and adequate management of bacterial meningitis considering that other micro-organisms than Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae can be involved.
    Medecine Et Maladies Infectieuses - MED MAL INFEC. 01/2002; 32(8):427-431.