Percutaneous left atrial appendage (LAA) closure represents an attractive alternative to oral anticoagulation for stroke prophylaxis in patients with non-valvular atrial fibrillation. A growing body of evidence on the AmplatzerTM Cardiac Plug, the AmplatzerTM Amulet Device and the WatchmanTM device appears to confirm the safety and effectiveness of device-based strategies for stroke prevention.
... [Show full abstract] However, several questions still remain unanswered, mainly regarding patient and device selection, and post-procedural antithrombotic treatment. The present review summarises the rationale for LAA closure and presents the current device landscape for percutaneous LAA occlusion.