A non-invasive co-imaging system of pO2 and pyruvate metabolism was developed to visualize the correlation between tumor oxygen status and energy metabolism. SCCVII and HT29 were compared when the size of both tumors was similar. We investigated the effect of single 5 Gy irradiation on the relationship in HT29 tumors. SCCVII has significantly larger hypoxic sub-region (pO2 < 8 mmHg) than HT29.
... [Show full abstract] Lactate/pyruvate ratio in 0-8mmHg of 1 day after 5Gy irradiation of HT29 is higher than of non irradiation of HT29 that is explained by decreased perfusion, decreased tumor pO2, and increased extracellular acidification rate.