A case of multiple aneurysmal fibrous histiocytomas: Correspondence

Keio University, Edo, Tōkyō, Japan
British Journal of Dermatology (Impact Factor: 4.1). 09/2005; 153(3):664-665. DOI: 10.1111/j.1365-2133.2005.06773.x
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    ABSTRACT: The term 'fibrohistiocytic' tumour is a descriptive designation without histogenetic connotation for a group of heterogeneous lesions that share morphological features of histiocytes and fibroblasts on light microscopy. However, over the years it has become apparent that many so-called 'fibrohistiocytic' tumours are largely composed of relatively undifferentiated mesenchymal cells, but can also show areas of myofibroblastic differentiation. This review focuses on the clinical and histological features as well as differential diagnosis of so-called fibrohistiocytic tumours. Special emphasis is given to more recently described histological variants of fibrous histiocytoma, e.g. cellular, epithelioid, aneurysmal and atypical fibrous histiocytoma, to angiomatous and plexiform fibrous histocytoma (plexiform fibrohistiocytic tumour), lesions that are not true variants of fibrous histiocytomas but have erroneously been designated such, and to atypical fibroxanthoma. The literature on metastasizing fibrous histiocytoma is also reviewed.
    Histopathology 01/2010; 56(1):148-65. DOI:10.1111/j.1365-2559.2009.03447.x · 3.30 Impact Factor
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    Advances in anatomic pathology 06/2008; 15(3):172-6. DOI:10.1097/PAP.0b013e3181709fa7 · 3.10 Impact Factor
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    ABSTRACT: The skin can be key to early diagnosis of systemic malignancies. In the second part of this review, we present various skin conditions that can, in certain contexts, reveal the presence of malignancy. The skin conditions are presented in groups based on a diverse range of morphological characteristics. Specifically, the following groups are analyzed: erosive and blistering lesions; inflammatory papules and nodules; xerosis, ichthyosis, and generalized exfoliative dermatitis; symptoms such as pruritus; abnormal hair distribution patterns; sweating disorders; benign tumors that can form part of hereditary syndromes associated with a risk of visceral cancer; and finally, oral and nail abnormalities. This review highlights the importance of the skin in the study of systemic malignancies.
    Actas Dermo-Sifiliográficas 08/2012; DOI:10.1016/