Abteilung Neuroonkologie, Nationales Zentrum für Tumorerkrankungen (NCT), Universitätsklinikum Heidelberg, sowie KKE Neuroimmunologie und Hirntumorimmunologie, Deutsches Krebsforschungszentrum Heidelberg.
[Show abstract][Hide abstract] ABSTRACT: Abstract Breast cancer is the most common type of
cancer among women and the survival of patients affected
by it is increasing, mainly due to several new approaches in
early diagnosis and more effective treatments. The enzyme
indoleamine 2,3-dioxygenase (IDO) is expressed in many
cells, including tumor cells. IDO acts by inhibiting the
proliferation of T lymphocytes, thus compromising their
cytotoxic activity. 1-Methyl-DL-tryptophan (1MT) is a
competitive inhibitor of IDO, which blocks its immunosuppressive
effect. Paclitaxel is an antineoplastic drug
largely used in breast cancer therapy. Thus, this study
aimed to determine the in vitro effect of the association of
1MT and paclitaxel chemotherapy, as an approach to
reduce tumor growth. It is believed that this would allow
the restoration of T lymphocyte proliferation capability and
its cytotoxic response. The supplemented cultures showed
that the most significant differences in the expression of
IDO were observed in the group treated with paclitaxel
associated with 1-MT continuous supplementation, reducing
enzyme expression from 12.06 to 3.56 %. This association
was more effective in reducing IDO expression and
could collaborate in developing a new therapeutic strategy
for breast cancer treatment.
Medical Oncology 09/2015; 32:248. DOI:10.1007/s12032-015-0694-8 · 2.63 Impact Factor
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