Article

An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

Molecules 01/2008; 13(4):716-728. DOI: 10.3390/molecules13040716
Source: DOAJ

ABSTRACT Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields, to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. This two step methodology improves upon previously described results. Poor e.e's resulted from our attempts to drive the enantioselectivity of this transformation by chiral amide induction.

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Jun 3, 2014