Congenital granular cell tumor or congenital epulis is a rare benign soft tissue lesion in newborns. It usually arises from the mucosa of the gingiva, either from the maxillary or mandibular alveolar ridge, and may cause respiratory or feeding problems. We reported a case of a 1-hour-old female newborn with a congenital granular cell tumor in the anterior maxillary alveolar ridge. The lesion was causing a feeding problem and was excised under general anesthesia when the newborn was 1 day old.
"The credit of first describing this lesion in literature goes to the German pathologist Dr. Franz Ernst Christian Neumann who in 1871 presented it as a " congenital epulis. " Epulis is a word derived from the ancient Greek language and translates into " swelling on the gingiva " . In medical literature , this lesion is known by many names such as Neumann tumor, Abrikosov tumor, granular cell myoblastoma, and so on; however, the recommended terminology by the World Health Organization is " congenital granular cell epulis " . "
[Show abstract][Hide abstract] ABSTRACT: Congenital granular cell epulis (CGCE) is an uncommon benign lesion found in newborns. It has predominance for females with an 8:1 ratio in relation to males and is exclusively encountered in the oral cavity. The most affected oral site is located around the canine/incisor region of the maxillary alveolar ridge, where the lesion arises from the soft tissue as a solitary pedunculated mass. CGCE's histogenesis remains obscure and controversial. We present a rare case of two separate CGCE lesions adjacent to each other measuring 23 x 18 x10 and 15 x 10 mm, positioned facially on the right maxillary alveolar process. The patient, a two-day old female newborn, did not experience any serious difficulty regarding breathing or deglutition. Complete surgical excision was the treatment of choice in this case and the procedure was performed under both general and local anesthesia. Histological and immunohistochemical analysis confirmed the diagnosis CGCE. The patient showed satisfactory post operative healing and excellent health at both the 10-day recall appointment and the six months follow-up.
"It has been suggested that the CGCT is merely a stage in the development of the tooth germ but the finding of occasional epithelial, ameloblastlike , cells among the granular cells does not constitute proof of this contention, since epithelial residues are rampant in all gingival tissues . Different studies discussed several theories: odontogenic, fibroblastic, hystocytic, myogenic and neurogenic, but the exact aetiology and histogenesis still remain uncertain   . "
[Show abstract][Hide abstract] ABSTRACT: Dentistry for babies aims to contribute to the formation of a generation with fewer dental problems, higher quality of oral health and more aware of the importance of prevention. The congenital gingival granular cell tumour (CGCT) is a rare benign soft tissue tumour in the newborn that can lead to respiratory difficulties and feeding. The aim of this work was to report two cases of CGCT in babies and discuss the clinical and histological differential diagnosis and their treatment, as well as the importance of knowledge of this pathology for dentists. Clinical features and treatment approaches are presented and discussed. The surgical approach improved the child quality of life and restored the parent's confidence and emotional stability. Knowledge of this pathology helps in better diagnosis and treatment, which lead to a better quality of life of children and return confidence and emotional stability to parents.
[Show abstract][Hide abstract] ABSTRACT: Congenital oral tumor masses might cause ventilation problems in the neonate. We report the first case of an EXIT procedure performed in a fetal granular cell tumor arising from the maxilla that was diagnosed prenatally followed by surgical correction on the 4th day of life. The EXIT procedure is an elegant approach to optimize perinatal airway management in such tumors.
Pediatric Surgery International 09/2010; 26(9):935-7. DOI:10.1007/s00383-010-2674-6 · 1.00 Impact Factor
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