Congenital Granular Cell Tumor

Department of Pediatrics, Umraniye Training and Research Hospital, Istanbul, Turkey.
The Journal of craniofacial surgery (Impact Factor: 0.68). 06/2009; 20(3):976-7. DOI: 10.1097/SCS.0b013e3181a2e1e5
Source: PubMed


Congenital granular cell tumor or congenital epulis is a rare benign soft tissue lesion in newborns. It usually arises from the mucosa of the gingiva, either from the maxillary or mandibular alveolar ridge, and may cause respiratory or feeding problems. We reported a case of a 1-hour-old female newborn with a congenital granular cell tumor in the anterior maxillary alveolar ridge. The lesion was causing a feeding problem and was excised under general anesthesia when the newborn was 1 day old.

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    • "It has been suggested that the CGCT is merely a stage in the development of the tooth germ but the finding of occasional epithelial, ameloblastlike , cells among the granular cells does not constitute proof of this contention, since epithelial residues are rampant in all gingival tissues [11]. Different studies discussed several theories: odontogenic, fibroblastic, hystocytic, myogenic and neurogenic, but the exact aetiology and histogenesis still remain uncertain [1] [5] [10]. "
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    ABSTRACT: Dentistry for babies aims to contribute to the formation of a generation with fewer dental problems, higher quality of oral health and more aware of the importance of prevention. The congenital gingival granular cell tumour (CGCT) is a rare benign soft tissue tumour in the newborn that can lead to respiratory difficulties and feeding. The aim of this work was to report two cases of CGCT in babies and discuss the clinical and histological differential diagnosis and their treatment, as well as the importance of knowledge of this pathology for dentists. Clinical features and treatment approaches are presented and discussed. The surgical approach improved the child quality of life and restored the parent's confidence and emotional stability. Knowledge of this pathology helps in better diagnosis and treatment, which lead to a better quality of life of children and return confidence and emotional stability to parents.
    03/2015; 9(1):ZD03-5. DOI:10.7860/JCDR/2015/10048.5409
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    ABSTRACT: Congenital oral tumor masses might cause ventilation problems in the neonate. We report the first case of an EXIT procedure performed in a fetal granular cell tumor arising from the maxilla that was diagnosed prenatally followed by surgical correction on the 4th day of life. The EXIT procedure is an elegant approach to optimize perinatal airway management in such tumors.
    Pediatric Surgery International 09/2010; 26(9):935-7. DOI:10.1007/s00383-010-2674-6 · 1.00 Impact Factor
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    ABSTRACT: Congenital granular cell lesion of the newborn, also known as congenital epulis, is a rare benign oral cavity tumor presenting at birth. Usually, it appears as a solitary mass arising in the mouth and originates from the anterior alveolar ridge. The objective of the present article is to report a case of congenital granular cell lesion in an 8-day-old female newborn. The patient presented four intraoral pedunculated lesions. Diagnosis, treatment, microscopic and immunohistochemical characteristics are also discussed.
    The Journal of clinical pediatric dentistry 09/2011; 36(1):71-4. DOI:10.17796/jcpd.36.1.y1x9526472206504 · 0.35 Impact Factor
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