Article

PET imaging of redox and energy states in stroke-like episodes of MELAS.

Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaiduki, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan.
Mitochondrion (impact factor: 3.62). 02/2009; 9(2):144-8. DOI:10.1016/j.mito.2009.01.011
Source: PubMed

ABSTRACT In stroke-like episodes of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), changes in oxidative stress and glucose metabolism and their sequence remain obscure. We developed a novel double imaging method using positron emission tomography (PET) with [(62)Cu]-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) and [(18)F]-fluorodeoxyglucose ((18)FDG) to visualize the regional oxidative stress, glucose metabolism and blood flow in brain lesions of stroke-like episodes non-invasively and rapidly. These PET imagings were performed on a MELAS patient with stroke-like lesions, and clearly demonstrated that oxidative stress following hyperemia along with increased glucose metabolism plays crucial roles in the pathogenesis of MELAS stroke-like episodes.

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    Proceedings of the National Academy of Sciences 12/2011; 109(1):47-52. · 9.68 Impact Factor
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Keywords

[(18)F]-fluorodeoxyglucose
 
blood flow
 
brain lesions
 
crucial roles
 
glucose metabolism
 
MELAS stroke-like episodes
 
mitochondrial myopathy
 
novel double imaging method
 
oxidative stress
 
pathogenesis
 
PET imagings
 
positron emission tomography
 
regional oxidative stress
 
stroke-like episodes
 
stroke-like episodes non-invasively
 
stroke-like lesions
 
visualize