Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene

Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan.
European Journal Of Haematology (Impact Factor: 2.07). 06/2009; 83(2):149-53. DOI: 10.1111/j.1600-0609.2009.01275.x
Source: PubMed


Mixed-lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy-related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL-AF4 fusion transcript. MLL-AF4 is derived from t(4;11)(q21:q23) and occurs exclusively in B-cell lineage leukemia. To our knowledge, MLL-AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL-AF4-associated leukemia.

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