Association between periodontal disease and metabolic syndrome.

Lion Foundation for Dental Health, Japan.
Journal of Public Health Dentistry (Impact Factor: 1.21). 05/2009; 69(4):248-53. DOI: 10.1111/j.1752-7325.2009.00130.x
Source: PubMed

ABSTRACT Metabolic syndrome is a complex medical disorder characterized by visceral fat-type obesity involving hypertension, and abnormal glucose and lipid metabolism. The objective of this study was to investigate the relationship between periodontal disease and components of metabolic syndrome (obesity, lipid abnormality, hypertension, and hyperglycemia) in industrial workers of a single company in Tokyo, Japan.
The study subjects consisted of 2478 adult employees (2028 men and 450 women; mean age: 43.3 years). The association between the presence of periodontal pockets and components of metabolic syndrome was investigated cross-sectionally using multiple logistic regression analysis, odds ratios (ORs), and 95 percent confidence intervals (CIs).
Body mass index, blood pressure, triglycerides, fasting blood glucose, and hemoglobin A1c (HbA1c) were significantly elevated (P < 0.05) in patients with periodontal pockets of 4 mm or more. We found that the OR of the presence of periodontal pockets adjusted for age, gender, and smoking habit was 1.8 (96 percent CI = 1.4-2.3) when the subjects with two positive components and without positive component were compared. And it was 2.4 (96 percent CI = 1.7-2.7) when the subjects with three or four positive components and without positive component were compared.
Our findings suggest an association between periodontal disease and metabolic syndrome in Japanese workers between the ages of 20 and 60 years.

1 Bookmark
  • [Show abstract] [Hide abstract]
    ABSTRACT: High-frequency radar offers oceanographers a powerful yet convenient means of measuring coastal ocean currents and other air/sea interaction variables from land-based sites. The paper addresses the potential such a system offers for detecting the physically significant coastal circulation events known as coastal upwelling and relaxation. A high-frequency radar was in operation from April, 1990 until September, 1992 on the California Coast (USA) overlooking the Pacific Ocean near Monterey. Periods of months of uninterrupted radar operation have allowed the production of an unparalleled data set which includes radial ocean surface currents measured at five angles and eight range bins. Correlation of low-pass-filtered current measurements with shore-based measurements of sea surface temperature and buoy-measured wind speeds shows evidence of coastal upwelling and relaxation events
    Geoscience and Remote Sensing Symposium, 1993. IGARSS '93. Better Understanding of Earth Environment., International; 09/1993
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background Metabolic Syndrome (MetS) is a conglomerate of several physical conditions/diseases that, as a group, increases the risk of mortality resulting from development of T2DM and cardiovascular diseases (CVD). These conditions/diseases include glucose intolerance/insulin resistance, hypertension, obesity, and dyslipidemia. The results from epidemiological studies suggest that there is an association between metabolic syndrome (MetS) and periodontitis, it is therefore important to understand the current status of the association and a possible contribution of periodontitis to MetS. Objective This review will qualitatively analyze published papers on the association of MetS and periodontitis/periodontal disease to clarify the current status of the association and suggest future directions for studies which may unravel the causal relationship between them. Results Of 309 papers related to MetS and periodontitis, 26 are original research papers that investigated the relationship/association between periodontal disease and MetS. Criteria used to assess periodontitis and MetS as well as overall study designs and patient recruitment criteria varied greatly among these studies. Conclusion All these studies demonstrated a positive association between periodontal disease and MetS. However, due to the heterogeneity of criteria to assess periodontitis and MetS and also paucity of longitudinal studies, it is difficult to determine the relative contribution of periodontitis to MetS. Age and the number of positive components of MetS appear to strengthen the relationship, however, incidence of each disease entity increases with aging. Thus, mechanistic studies are also necessary to unravel the inter-relationship between periodontitis and MetS. In this regard, a use of animal models will be helpful as they are more uniform in regards to genetic background and have minimum confounding factors. Finally, development of accurate, quantitative assessment of gingival inflammation are necessary in order to determine the influence of periodontal disease on the development of MetS and its components.
    Archives of Oral Biology. 01/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: The objective of this study was to characterize the association between metabolic syndrome (Metsyn) and periodontitis in women, for which there is limited evidence. Methods: Cross-sectional associations between Metsyn and periodontitis were examined in 657 postmenopausal women age 50-79 years enrolled in a periodontal disease study ancillary to the Women's Health Initiative Observational Study. Whole mouth measures of alveolar crestal height (ACH), clinical attachment level (CAL), probing depth (PD), gingival bleeding and supragingival plaque, and measures to define Metsyn using National Cholesterol Education Program criteria were from a clinical examination. Study outcomes were defined as: (1) mean ACH ≥3mm, or 2 sites ≥5mm, or tooth loss to periodontitis; (2) ≥2 sites with CAL ≥6mm and ≥1 site with PD ≥5mm; (3) gingival bleeding at ≥50% of sites; and (4) supragingival plaque at ≥50% of sites. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: In unadjusted analyses, Metsyn (prevalence, 25.6%) was significantly associated with supragingival plaque (OR, 1.74, 95% CI: 1.22, 2.50) and nonsignificantly associated with periodontitis defined by ACH (OR, 1.23, 95% CI: 0.81, 1.85) and gingival bleeding (OR, 1.20, 95% CI: 0.81, 1.77). Adjustment for age, smoking and other confounders attenuated observed associations, though supragingival plaque remained significant (OR, 1.47, 95% CI: 1.00, 2.16, p = .049). Metsyn was not associated with periodontitis defined by CAL and PD. Conclusions: A consistent association between Metsyn and measures of periodontitis was not seen in this cohort of postmenopausal women. An association between Metsyn and supragingival plaque requires further investigation.
    Journal of periodontology. 05/2014;