A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia. Schizophr Res 113(2-3):167-175

Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Schizophrenia Research (Impact Factor: 3.92). 06/2009; 113(2-3):167-75. DOI: 10.1016/j.schres.2009.04.020
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The severity and profile of cognitive dysfunction in first episode schizophrenia and psychotic affective disorders were compared before and after antipsychotic treatment. Parallel recruitment of consecutively admitted study-eligible first-episode psychotic patients (30 schizophrenia, 22 bipolar with psychosis, and 21 psychotic depression) reduced confounds of acute and chronic disease/medication effects as well as differential treatment and course. Patient groups completed a neuropsychological battery and were demographically similar to healthy controls (n=41) studied in parallel. Prior to treatment, schizophrenia patients displayed significant deficits in all cognitive domains. The two psychotic affective groups were also impaired overall, generally performing intermediate between the schizophrenia and healthy comparison groups. No profile differences in neuropsychological deficits were observed across patient groups. Following 6 weeks of treatment, no patient group improved more than practice effects seen in healthy individuals, and level of performance improvement was similar for affective psychosis and schizophrenia groups. Although less severe in psychotic affective disorders, similar profiles of generalized neuropsychological deficits were observed across patient groups. Recovery of cognitive function after clinical stabilization was similar in mood disorders and schizophrenia. To the extent that these findings are generalizable, neuropsychological deficits in psychotic affective disorders, like schizophrenia, may be trait-like deficits with persistent functional implications.

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    • "Instead, genetic effects appear to be small and polygenic (Buckholtz & Meyer- Lindenberg, 2012), and do not adhere to traditional diagnostic boundaries (Kendell & Jablensky, 2003). Likewise, endophenotypes such as cognitive alterations also occur in multiple disorders rather than showing disorder-specific associations (Weiser et al. 2005; Hill et al. 2009; Buckholtz & Meyer-Lindenberg, 2012). "
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    Psychological Medicine 03/2015; 45(11):1-13. DOI:10.1017/S0033291715000331 · 5.94 Impact Factor
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    • "Cognitive deficits persist despite clinical improvement (Poletti et al., 2014) and although the euthymic state has been associated with better performances compared to the other states, it still involves cognitive impairment in comparison with healthy controls (Malhi et al., 2007, 2004). Neuropsychological deficits are thus considered enduring trait-like features of BD (Burdick et al., 2006; Hill et al., 2009). "
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    Journal of Affective Disorders 12/2014; 174C:342-352. DOI:10.1016/j.jad.2014.12.030 · 3.38 Impact Factor
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    • "Because acute illness may disrupt inhibitory control in bipolar disorder (Strakowski et al., 2010) and schizophrenia (Harris et al., 2006; Hill et al., 2009), patients were clinically stable and on consistent psychopharmacological treatment for at least one month. Symptom severity and functioning were rated using the Positive and Negative Symptom Scale (Lancon et al., 2000), Young Mania Rating Scale (Young et al., 2000), Montgomery–Asberg Depression Rating Scale (Montgomery and Asberg, 1979), Birchwood Social Functioning Scale (Birchwood et al., 1990), Schizo-bipolar Scale (Keshavan et al., 2011) and Barratt Impulsiveness Scale 11 (Patton et al., 1995). "
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