Article

Two new biphenanthrenes with cytotoxic activity from Bulbophyllum odoratissimum.

Department of Chemistry, Yunnan Normal University, Kunming 650092, China.
Fitoterapia (impact factor: 1.85). 06/2009; 80(7):381-4. DOI:10.1016/j.fitote.2009.05.007 pp.381-4
Source: PubMed

ABSTRACT Two new dimeric phenanthrenes, bulbophythrins A (1) and B (2), were isolated from Bulbophyllum odoratissimum. Their structures were elucidated by HR-ESI-MS, 1D and 2DNMR spectroscopy. They were evaluated in vitro for their inhibitory ability against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer SGC-7901. Both compounds showed significant cytotoxicity against the tested cell lines. Compound 1 exhibited some selectivity against HL-60 and BEL-7402 with IC(50) values of 1.27 x 10(-3) and 1.22 x 10(-3) micromol/ml respectively, whereas 2 was most active against A549 with IC(50) value of 1.18 x 10(-3) micromol/ml.

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Keywords

human hepatoma BEL-7402
 
human leukemia cell lines K562
 
human lung adenocarcinoma A549
 
human stomach cancer SGC-7901
 
inhibitory ability
 
new dimeric phenanthrenes
 
selectivity
 
significant cytotoxicity
 
structures
 
tested cell lines