Tuberculosis after Solid-Organ Transplant: Incidence, Risk Factors, and Clinical Characteristics in the RESITRA (Spanish Network of Infection in Transplantation) Cohort

Clinic Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Avda. Menééndez Pidal, Córdoba 14004, Spain.
Clinical Infectious Diseases (Impact Factor: 8.89). 06/2009; 48(12):1657-65. DOI: 10.1086/599035
Source: PubMed


It is necessary to clarify the incidence of and risk factors for tuberculosis (TB) among solid-organ transplant (SOT) recipients as well as changes in the chronology, clinical presentation, and prognosis of the disease.
A total of 4388 SOT recipients were monitored prospectively at 16 transplant centers included in the Spanish Network for Research in Infectious Diseases (REIPI). TB episodes were studied, and the incidence rate was calculated. Certain variables were analyzed, by Cox regression analysis, as potential risk factors for TB.
Among the 4388 SOT recipients, 21 cases of TB were reported (0.48%). The median duration of follow-up was 360 days (range, 0-720 days). The global incidence of TB was 512 cases per 10(5) patients per year (95% confidence interval [CI], 317-783), which was higher than that in the general population in Spain (18.9 cases per 10(5) inhabitants per year; relative risk [RR], 26.6). The highest incidence (2072 cases per 10(5) patients per year; 95% CI, 565-5306) was observed among lung transplant recipients (RR, 73.3). Of the TB cases, 95% occurred within the first year after transplant, and 76% were pulmonary forms. Crude mortality was 19.0%, and attributable mortality was 9.5%. Multivariate analysis identified recipient age (RR, 1.05; 95% CI, 1.0-1.1) and receipt of a lung transplant (RR, 5.6; 95%, 1.9-16.9) as independent risk factors.
TB incidence is increased among SOT recipients. The risk factors identified were age and receipt of a lung transplant. TB-attributable mortality (9.5%) is still high.

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Available from: Jordi Carratalá, Oct 02, 2014
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    • "The incidence of post transplant tuberculosis varies from 0.48% in the west [22] to 11.8% in India [23]. Therapeutic response is often satisfactory and drug interactions mandate dose adjustment of other immunosuppression drugs as well as azoles. "
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    • "Prophylaxis with isoniazid was used in the single patient with positive PPD in the pre-transplant period, but the patient stopped the treatment after 4 months. TBrelated mortality was the same in studies performed between 1980 and 1994 (20.5% vs. 20%), but it still remains higher than that in studies performed between 2003 and 2006 in developed countries (20.5% vs. 9.5%) (Aguado et al. 1997; Torre-Cisneros et al. 2009). "
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