Implantable diagnostic device for cancer monitoring. Biosens Bioelectron

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biosensors & Bioelectronics (Impact Factor: 6.41). 05/2009; 24(11):3252-7. DOI: 10.1016/j.bios.2009.04.010
Source: PubMed


Biopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. The ability to repeatedly sample the local environment for tumor biomarker, chemotherapeutic agent, and tumor metabolite concentrations could improve early detection of metastasis and personalized therapy. Here we describe an implantable diagnostic device that senses the local in vivo environment. This device, which could be left behind during biopsy, uses a semi-permeable membrane to contain nanoparticle magnetic relaxation switches. A cell line secreting a model cancer biomarker produced ectopic tumors in mice. The transverse relaxation time (T(2)) of devices in tumor-bearing mice was 20+/-10% lower than devices in control mice after 1 day by magnetic resonance imaging (p<0.01). Short term applications for this device are numerous, including verification of successful tumor resection. This may represent the first continuous monitoring device for soluble cancer biomarkers in vivo.

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Available from: Michael J. Cima, Apr 20, 2015
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    • "In addition there may be opportunities to introduce temporary implanted sensors where tissue needs local monitoring over shorter times. An example of such a device is an implantable sensor for cancer marker proteins that can be left in situ during tumour surgery to monitor local tissue response (Daniel et al., 2009). The sensor contains an implanted magnetic label sensitive to cancer markers which can diffuse into the device. "
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    • "Magnetic nanoparticles have been widely used in cancer cell imaging. By using the principle of decrease in transverse relaxation time due to aggregation of magnetic nanoparticles in presence of target molecules, concentration of cancer biomarkers could be measured [71]. This device allowed in vivo, local environment monitoring for cancer biomarkers and could be left implanted after tumor surgery. "
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