Article

Association study on the NAPG gene and bipolar disorder in the Chinese Han population.

Bio-X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University,1954 Hushan Road, Shanghai 200030, PR China.
Neuroscience Letters (impact factor: 2.11). 08/2009; 457(3):159-62. DOI:10.1016/j.neulet.2009.03.070 pp.159-62
Source: PubMed

ABSTRACT Bipolar disorder is a mental health problem throughout the world. Chromosome 18p11 has been identified by several studies as a susceptiblilty region for bipolar disorder and NAPG, located on 18p11, has been suggested as being associated with bipolar disorder in European population.
Our study employed five SNPs (rs2290279, rs495484, rs510110, rs617040 and rs473938) to investigate the role of NAPG in the Chinese Han population based on a sample of 465 controls vs. 499 bipolar patients.
Rs617040 was excluded from further analysis because of deviation from Hardy-Weinberg equilibrium. Rs473938 and rs2290279 showed significant association in both allele and genotype frequencies (rs473938: allele p=0.0028 after 100,000 permutations, genotype p=0.0018; rs2290279: allele p=0.0042 after 100,000 permutations, genotype p=0.0028). Several combinations of haplotype were found to be associated with bipolar disorder. Haplotype T-A-T of rs473938-rs2290279-rs495484 was defined by confidence intervals algorithm and had a p value of 0.0038 after 100,000 permutations.
Our study supports NAPG as a candidate for susceptibility to bipolar disorder.

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Keywords

499 bipolar patients
 
bipolar disorder
 
Chinese Han population
 
confidence intervals algorithm
 
European population
 
genotype frequencies
 
haplotype
 
Haplotype T-A-T
 
Hardy-Weinberg equilibrium
 
mental health problem
 
significant association
 
SNPs
 
susceptibility
 
susceptiblilty region