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Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats

Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea.
Neuroscience Letters (Impact Factor: 2.06). 05/2009; 453(3):151-6. DOI: 10.1016/j.neulet.2009.01.076
Source: PubMed

ABSTRACT Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety. Many studies have shown that acupuncture, which is widely used for the treatment of stress and mental illness, in East Asian countries, is an effective therapeutic intervention for psychosomatic disorders. We investigated the influence of acupuncture therapy on chronic CORT-induced behavioral responses to the forced swimming test (FST) and elevated plus maze (EPM) and expression of neuropeptide Y (NPY) in the rat brain using immunohistochemistry. Male Sprague-Dawley rats were injected with CORT (40 mg/kg, i.p.) once daily for 19 consecutive days. The dysregulation of HPA axis by external injection of CORT was confirmed by measuring the CORT concentration in plasma and the expression level of CRF in hypothalamus. Acupuncture was performed at the PC6 acupoint for 5 min before CORT injection. Acupuncture significantly reduced depression- and anxiety-like behavior and increased NPY expression in the hypothalamus. These results demonstrated that stimulation of the PC6 acupoint suppresses the symptopathology of the hypoactivated HPA axis in chronic CORT-induced rat model of depression.

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    • "In East Asian nations, acupuncture has been widely used as a therapeutic method to treat many psychosomatic disorders including major depression, stress, and drug abuse [12]. Its therapeutic effects and mechanisms have been investigated in both clinical and animal studies. "
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    • "e l s e v i e r . c o m / l o c a t e / n c i depressive-like symptoms (Dwivedi et al., 2006; Johnson et al., 2006; Murray et al., 2008; Lee et al., 2009; Zhao et al., 2009; Crupi et al., 2010), while antidepressants and acupuncture treatment could significantly reverse these changes (Lee et al., 2009; Crupi et al., 2010). These findings suggest that corticosteronetreated rodents may be a valid depression model to evaluate the efficacy of antidepressant candidates and explore the mechanism of action of antidepressants (Zhao et al., 2008; Iijima et al., 2010). "
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    • "Electroacupuncture (EA) is one of the most frequently used therapeutic modalities for mental disorders, particularly in the East [1,2]. A growing number of studies have demonstrated the antidepressant-like effects of EA [3,4]. However, the neural mechanisms underlying the antidepressant-like effects of EA on depression remain complicated. "
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