Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi-ethnic European city

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Journal of Gastroenterology and Hepatology (Impact Factor: 3.63). 06/2013; 28(11). DOI: 10.1111/jgh.12315
Source: PubMed

ABSTRACT At the same time that H. pylori prevalence is declining in Western countries, immigrants from developing countries with high H. pylori prevalence have settled in Western urban areas. Actual epidemiologic data on H. pylori in a migrant community may help in realizing a more selective approach to assess H. pylori-related diseases. We aimed to define H. pylori prevalence as well as risk groups for H. pylori in a cohort of young women living in a multi-ethnic European city.
We measured IgG anti-H. pylori and CagA-antibodies in serum of pregnant women included in a population-based prospective cohort study. Information on demographics, and socio-economic status was collected by questionnaires. Chi-square and logistic regression were used.
In total, 3146 (46%) of the 6837 tested women (mean age 29.7 ± 5.3) were H. pylori-positive and 1110 (35%) of them were CagA-positive. The H. pylori prevalence in Dutch women was 24%, which was significantly lower than in non-Dutch women (64%; p<0.001). In particular, H. pylori positivity was found in 92% of Moroccan (OR 19.2; 95% CI 11.8-32.0), 80% of Cape Verdean (7.6; 5.0-11.5), 81% of Turkish (9.0; 6.7-12.1), 60% of Dutch Antillean (3.3; 2.3-4.7), and 58% of Surinamese women (3.0; 2.3-3.8). Among H. pylori-positive Dutch subjects, 19% were CagA-positive compared with 40% of the non-Dutch subjects (p<0.001).
Despite a general trend of declining prevalence in Western countries, H. pylori remains highly prevalent in migrant communities, which may constitute target groups for screening and eradication to prevent H. pylori-related diseases.

  • [Show abstract] [Hide abstract]
    ABSTRACT: The stomach has a range of functions, including chemical digestion and mechanical breakdown of food, temporary storage of bulk intake, and regulation of the passage of nutrients into the duodenum. Further gastric functions are the nonspecific defense against microbes entering the gastrointestinal tract, preparation of ions as well as liberation of protein-bound cobalamin and production of intrinsic factor for uptake further along the tract, and finally limited absorption of water, alcohol, and some fat-soluble food components including some drugs. These functions are influenced by various lifestyle factors, such as smoking and alcohol intake with interference by Helicobacter pylori colonization. This paper focuses on the interaction between lifestyle and gastric function. © 2014 S. Karger AG, Basel.
    Digestive Diseases 01/2014; 32(3):202-5. DOI:10.1159/000357850 · 1.83 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background. Noroviruses (NoVs) represent a considerable public health burden, but despite their enormous genetic diversity, most outbreaks are due to the single GII.4 genotype for poorly understood reasons. NoVs use histo-blood group antigens (HBGAs) as attachment factors. Since HBGAs are present in saliva, binding of strains to saliva is commonly used as a surrogate for recognition of the gut surface by specific strains, although the relationship between saliva and gut tissue expression of HBGAs is not well definedMethods. The presence of fucosylated HBGAs in saliva and stomach biopsies, as well as that of GI.1 and GII.4 virus-like particles were compared in a series of 109 donors selected for dyspepsia.Results. An overall good concordance between HBGA expression in saliva and stomach surface mucosa was observed. However, unexpected mucosa expression of α1,2fucosylated epitopes in nonsecretor individuals was frequently detected, allowing for GII.4 attachment. Although all individuals were Helicobacter pylori (Hp) infected, abnormal expression of α1,2fucosylated motifs and binding of GII.4 VLP in nonsecretors mucosa were associated with positivity for the Hp CagA virulence factor.Conclusions. Infection by CagA+ Hp induces expression of GII.4 attachment factors in nonsecretors mucosa, expanding these strains host-range and thereby possibly contributing to their epidemiological dominance.
    The Journal of Infectious Diseases 01/2014; 210(2). DOI:10.1093/infdis/jiu054 · 5.78 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Medline and PubMed databases were searched on epidemiology of Helicobacter pylori for the period of April 2013–March 2014. Several studies have shown that the prevalence of H. pylori is still high in most countries. In north European and North American populations, about one-third of adults are still infected, whereas in south and east Europe, South America, and Asia, the prevalence of H. pylori is often higher than 50%. H. pylori remains highly prevalent in immigrants coming from countries with high prevalence of H. pylori. However, the lower prevalence of infection in the younger generations suggests a further decline of H. pylori prevalence in the coming decades. Low socioeconomic conditions in childhood are confirmed to be the most important risk factors for H. pylori infection. Although the way the infection is transmitted is still unclear, interpersonal transmission appears to be the main route. Finally, H. pylori recurrence after successful eradication can still occur, but seems to be an infrequent event.
    Helicobacter 09/2014; 19(s1). DOI:10.1111/hel.12165 · 2.99 Impact Factor
Show more