Article

Regional Lung Density Changes After Radiation Therapy for Tumors in and Around Thorax

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27599-7512, USA.
International journal of radiation oncology, biology, physics (Impact Factor: 4.18). 04/2009; 76(1):116-22. DOI: 10.1016/j.ijrobp.2009.01.025
Source: PubMed

ABSTRACT To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors.
Between 1991 and 2004, 118 patients with interpretable pre- and post-radiation therapy (RT) chest computed tomography (CT) scans were evaluated. Changes in regional lung density were related to regional dose to define a dose-response curve (DRC) for RT-induced lung injury using three-dimensional planning tools and image fusion. Multiple post-RT follow-up CT scans were evaluated by fitting linear-quadratic models of density changes on dose with time as the covariate. Various patient- and treatment-related factors were examined as well.
There was a dose-dependent increase in regional lung density at nearly all post-RT follow-up intervals. The population volume-weighted changes evolved over the initial 6-month period after RT and reached a plateau thereafter (p < 0.001). On univariate analysis, patient age greater than 65 years (p = 0.003) and/or the use of pre-RT surgery (p < 0.001) were associated with significantly greater changes in CT density at both 6 and 12 months after RT, but the magnitude of this effect was modest.
There appears to be a temporal nature for the dose-dependent increases in lung density. Nondosimetric clinical factors tend to have no, or a modest, impact on these changes.

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    Physica Medica 10/2014; DOI:10.1016/j.ejmp.2014.10.006 · 1.85 Impact Factor
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