Serological testing for celiac disease in women with endometriosis. A pilot study.
ABSTRACT Celiac disease (CD) involves immunologically mediated intestinal damage with consequent micronutrient malabsorption and varied clinical manifestations, and there is a controversial association with infertility. The objective of the present study was to determine the presence of CD in a population of infertile women with endometriosis.
A total of 120 women with a diagnosis of endometriosis confirmed by laparoscopy (study group) and 1,500 healthy female donors aged 18 to 45 years were tested for CD by the determination of IgA-transglutaminase antibody against human tissue transglutaminase (t-TGA) and anti-endomysium (anti-EMA) antibodies.
Nine of the 120 women in the study group were anti-tTGA positive and five of them were also anti-EMA positive. Four of these five patients were submitted to intestinal biopsy which revealed CD in three cases (2.5% prevalence). The overall CD prevalence among the population control group was 1:136 women (0.66%).
This is the first study reporting the prevalence of CD among women with endometriosis, showing that CD is common in this population group (2.5%) and may be clinically relevant.
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ABSTRACT: Studies of recent years show that diet intervention can be a supportive therapy in management of certain reproductive system disorders, including infertility. A review of literature about mechanisms of fertility affected by systemic effects of food al-lergy, gluten sensitivity, lectins, and biologically active peptides derived from food involved in opioid regulation of reproductive physiology is presented in this paper. Additionally, lifestyle and dietary habits leading to a change in body mass, underweight or obesity, and metabolic deregulation resulting in subfertility have been discussed. INTRODUCTION Diet-dependent diseases are an increasing epide-miological problem in the world. Diet therapy can be a part of the management of many diseases including food allergies and intolerance, diabetes mellitus, obesity, hypercholesterolemia, hypertension, osteoporosis, renal diseases, autism, and others. Studies of recent years show that diet intervention can be a supportive therapy in management of certain reproductive system disorders, including infertility. Despite the increasing number of studies, the connection between fertility and nutrition is still underestimated. Infertility is classically defined as the inability to conceive after one year of regular intercourse without contraception . In Europe the prevalence of infertility is estimated to be above 15%. Evaluation of infertility usually identifies different causes, including male infertility (30%), female infertility (35%), the combination of both (20%), and finally unexplai-ned or "idiopathic" infertility (15%). The etiology of reproductive failure may be very complex owing to a neuroendocrine-immune association . The aim of the article: a review of literature about mechanisms of fertility affected by systemic effects of food allergy, gluten sensitivity or by activity of exorphins, lectins, and biologically active peptides derived from diet involved in opioid regulation of reproductive phy-siology is presented in this paper. Additionally, lifestyle and dietary habits leading to a change in body mass, underweight or obesity, and metabolic deregulation resulting in subfertility have been discussed.Sveikatos mokslai. 03/2011; 21(3-3):40-44.
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ABSTRACT: In the last years, a potential link between endometriosis and celiac disease has been hypothesized since these disorders share some similarities, specifically concerning a potential role of oxidative stress, inflammation, and immunological dysfunctions. We investigated the prevalence of celiac disease among Italian women with endometriosis with respect to general population. Consecutive women with a laparoscopic and histological confirmed diagnosis of endometriosis were enrolled; female nurses of our institution, without a known history of endometriosis, were enrolled as controls. IgA endomysial and tissue transglutaminase antibodies measurement and serum total IgA dosage were performed in both groups. An upper digestive endoscopy with an intestinal biopsy was performed in case of antibodies positivity. Presence of infertility, miscarriage, coexistence of other autoimmune diseases, and family history of autoimmune diseases was also investigated in all subjects. Celiac disease was diagnosed in 5 of 223 women with endometriosis and in 2 of 246 controls (2.2% versus 0.8%; P = 0.265). Patients with endometriosis showed a largely higher rate of infertility compared to control group (27.4% versus 2.4%; P < 0.001). Our results confirm that also in Italian population an increased prevalence of celiac disease among patients with endometriosis is found, although this trend does not reach the statistical significance.BioMed research international. 01/2014; 2014:236821.
- Archives of Gynecology 06/2013; · 1.28 Impact Factor