A prototype hybrid intraoperative probe for ovarian cancer detection

University of Connecticut, Department of Electrical and Computer Engineering, Storrs, CT 06269, USA.
Optics Express (Impact Factor: 3.53). 05/2009; 17(9):7245-58. DOI: 10.1364/OE.17.007245
Source: PubMed

ABSTRACT A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl(204)/Cs(137) sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study used optical coherence tomography (OCT) compared to scanning electron microscopy (SEM) and optical microscopy (OM) to evaluate qualitatively crack propagation and final fracture in restorative composite materials - Filtek Z250 and Filtek Z350 (3M ESPE) - with fiber reinforcement after cyclic loading. Samples were made using a split mold. Initially, 3-point bending tests were performed to determine the maximum force and tension at the fracture moment using samples without fiber reinforcement. Then, mechanical cycling tests were performed using samples with glass fiber embedded internally. The failures were analyzed using the 3 methods described before. OCT permitted good characterization of internal crack propagation of the dental composites, which, however, could not be visualized by either SEM or OM. OCT was proven to be laboratory research tool that is easy to use, does not require any specific preparation of the samples, and is less expensive than SEM.
    Brazilian dental journal 01/2010; 21(5):420-7. DOI:10.1590/S0103-64402010000500008
  • [Show abstract] [Hide abstract]
    ABSTRACT: A review is presented on a selection of methods and devices initially developed by the fiber optic, sensing and fiber laser communities which have later found applications in high resolution non-invasive optical imaging. Three avenues have been identified in the modern low coherence interferometry and in the optical coherence tomography technologies which have taken inspiration from fiber optic sensing, fiber optic devices, fiber lasers and fiber optic communications: 1) optical sources; 2) optical configurations; and 3) signal processing. The review will illustrate state of the art examples of concept evolution along these three avenues.
    Journal of Lightwave Technology 03/2010; DOI:10.1109/JLT.2009.2032787 · 2.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25mum X 25mum X 12mum - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.
    Proceedings of SPIE - The International Society for Optical Engineering 02/2011; DOI:10.1117/12.878860 · 0.20 Impact Factor
Show more