Article

Adult Supratentorial Low-Grade Glioma: Long-Term Experience at a Single Institution

Department of Oncology, London Health Sciences Center, University of Western Ontario, London, ON, Canada.
International journal of radiation oncology, biology, physics (Impact Factor: 4.18). 05/2009; 75(5):1401-7. DOI: 10.1016/j.ijrobp.2009.01.010
Source: PubMed

ABSTRACT To report the long-term follow-up of a cohort of adult patients with supratentorial low-grade glioma treated at a single institution.
A cohort of 145 adult patients treated at the London Regional Cancer Program between 1979 and 1995 was reviewed.
With a median follow-up of 105 months, the median progression-free survival was 61 months (95% confidence interval, 53-77), and the median overall survival was 118 months (95% confidence interval, 93-129). The 10- and 20-year progression-free and overall survival rate was 18% and 0% and 48% and 22%, respectively. Cox regression analysis confirmed the importance of age, histologic type, presence of seizures, Karnofsky performance status, and initial extent of surgery as prognostic variables for overall and cause-specific survival. Function among long-term survivors without tumor progression was good to excellent for most patients.
Low-grade glioma is a chronic disease, with most patients dying of their disease. However, long-term survival with good function is possible. Survival is determined primarily by the disease factors with selection and timing of adjuvant treatments having less influence on outcome.

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