Irritable bowel syndrome in childhood: Visceral hypersensitivity and psychosocial aspects
ABSTRACT Visceral hypersensitivity is often considered to play a major etiologic role in the pathophysiology of irritable bowel syndrome in adults, and some authors argue that this increased sensitivity is mainly due to psychological factors. In contrast, there are no data in children with irritable bowel syndrome which confirm this relationship. The aim of the study was to evaluate the relationship between psychosocial aspects and sensorymotor function in children affected by irritable bowel syndrome. Ten children fulfilling the Rome II criteria for irritable bowel syndrome and seven healthy controls were enrolled. We studied the thresholds and the perception of visceral stimuli in the rectum by means of an electronic barostat (isobaric phasic distentions, 3 mmHg/1 min, interval 1 min) and a validated questionnaire. Personality features were evaluated by means of the Big Five Questionnaire for Children. Sleep, mood disturbance, anxiety and individual performance (missed school days, school results and social activities) were also evaluated. Children with irritable bowel syndrome showed significantly lower thresholds for discomfort (14.8 +/- 3.5 vs 22.3 +/- 6.9 mmHg, P = 0.010) and a higher cumulative perception score (28.2 +/- 11.1 vs 12.3 +/- 8.0, P = 0.005) compared with healthy controls. A higher emotional instability (57.8 +/- 7.0 vs 48.7 +/- 10.1, P = 0.047), sleep disturbance (7.2 +/- 1.0 vs 9.3 +/- 0.5, P = 0.004) and anxiety (6.3 +/- 2.0 vs 2.3 +/- 1.7, P = 0.009) were observed in irritable bowel syndrome patients. Moreover, in a multivariate analysis, the cumulative perception score was significantly related to emotional instability (P = 0.042). In conclusion children with irritable bowel syndrome exhibit visceral hypersensitivity and psychosocial impairment. Emotional instability, as a personality feature in these children, seems to modulate the perception response to visceral stimulations.
- SourceAvailable from: slop.it
[Show abstract] [Hide abstract]
- "Children with FAP show a heightened sensitivity to detect visceral sensations, and exhibit a lower threshold for discomfort than unaffected children (Di Lorenzo et al., 2001; Iovino et al., 2009; Van Ginkel, Voskuljl, Benninga, Taminiau, & Boeckxstaens , 2001). Iovino et al. (2009) also report that emotional instability is associated with heightened visceral perception in youth with FAP. Other studies have reported a general hypersensitivity to sensory stimuli in children with FAP, including hypersensitivity to gastrointestinal sensations evoked by a water load (Walker et al., 2006) and excessive muscle tenderness and a lowered pressure-pain threshold (Alfvén, 1993b; Duarte, Goulart, & Penna, 2000). "
ABSTRACT: Medically unexplained physical symptoms, commonly referred to as functional somatic symptoms (FSS), are common in pediatric medical settings and associated with suffering, impairment, and medical help seeking. The association of pediatric FSS with anxiety and depressive symptoms and disorders across the life span is reviewed. Review and critique of controlled studies examining cross-sectional and longitudinal associations of FSS with anxiety and depressive symptoms and disorders in community-based and clinical samples of children and adolescents. FSS are consistently associated cross-sectionally with anxiety and depressive symptoms and disorders in childhood and adolescence, and the likelihood of associated anxiety and depression increases with the number of reported FSS. The presence of one or more FSS early in life is associated with an increased likelihood of multiple FSS and anxiety and depressive symptoms and disorders later in life, and anxiety and depressive symptoms and disorders in childhood are associated with subsequent multiple FSS. Strong associations between FSS, anxiety, and depression across the life span suggest the need to reconsider existing nosology and reconceptualize symptomatic relationships. Large, population-based longitudinal studies of FSS, anxiety, and depressive symptoms and disorders are needed to establish temporal relationships between the various symptoms and conditions.Journal of Child Psychology and Psychiatry 03/2012; 53(5):575-92. DOI:10.1111/j.1469-7610.2012.02535.x · 5.67 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A test bench has been designed and assembled for experimental study of the electrical behaviour of nonlinear active devices operating under multichromatic excitation. Based on the use of two six-port reflectometers, it can synthesize simultaneously five source and load impedances seen by the device under test. Two-tone measurements performed on an NE 9001 transistor operated in resistive mixer mode show that the linearity of the mixer can be improved by choice of appropriate termination impedancesElectrical and Computer Engineering, 1995. Canadian Conference on; 10/1995
- [Show abstract] [Hide abstract]
ABSTRACT: In adults, irritable bowel syndrome (IBS) and functional dyspepsia (FD) are chronic conditions that often start during childhood. We investigated mucosal serotonin (5-HT) signaling in children with the idea that data from subjects with a shorter history may improve our understanding of underlying pathophysiological mechanisms. Ninety-eight children undergoing gastroscopy or colonoscopy were studied prospectively. Biopsy specimens were evaluated for inflammation, enterochromaffin cell numbers, 5-HT content, and messenger RNA (mRNA) levels for the synthetic enzyme, tryptophan hydroxylase 1, and the serotonin transporter (SERT) were assessed by quantitative real-time reverse-transcription polymerase chain reaction. Data from 12 children with IBS and 17 with FD were compared with age-matched controls (12 with rectal biopsies and 12 with gastric biopsies) and with subjects with organic disorders. In patients with FD, a small number of immune cells were observed in the gastric mucosa in half of the patients, but no abnormalities with respect to the 5-HT pathway were identified. In patients with IBS, no differences were detected between patients and controls regarding intraepithelial lymphocytes and CD3+ cells in the lamina propria although all patients showed at least a slight inflammatory infiltrate. In the IBS samples, higher 5-HT content (P < .01) and lower SERT mRNA (P < .05) were detected as compared with controls. Severe inflammation in the colonic mucosa had a high impact on 5-HT signaling with a significant decrease in enterochromaffin cells (P < .01) and 5-HT content (P < .01) and a high SERT mRNA expression (P < .01). These results confirm the role of 5-HT signaling in IBS in children and argue against such a role in FD.Gastroenterology 03/2010; 139(1):249-58. DOI:10.1053/j.gastro.2010.03.032 · 13.93 Impact Factor