Article

The WAVE regulatory complex is inhibited.

Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA.
Nature Structural &#38 Molecular Biology (impact factor: 12.71). 05/2009; 16(5):561-3. DOI:10.1038/nsmb.1587 pp.561-3
Source: PubMed

ABSTRACT The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

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Keywords

actin nucleator Arp2/3 complex
 
Arp2/3 complex
 
observations
 
proteins
 
Rac
 
Rac GTPase
 
WAVE inhibition
 
WAVE regulatory complex
 
WAVE/WASP family
 

Ayman M Ismail